Matches in SemOpenAlex for { <https://semopenalex.org/work/W44560851> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W44560851 endingPage "44.1" @default.
- W44560851 startingPage "44.1" @default.
- W44560851 abstract "Abstract A hallmark of adaptive immunity is the formation of germinal centers that generate long-lived plasma cells and memory B cells. These events are undesirable by autoreactive B cells since they would lead the production of pathogenic autoantibodies and memory B cells that would accrue over a lifetime, but is unknown at a molecular level how this is achieved. To address this question we examined the ability of B cells specific for the SLE-specific self-antigen Sm to respond to antigen in vivo in the presence of functional T cells. Sheep red blood cells (SRBC) have an antigen that binds anti-Sm B cells and therefore immunization of anti-Sm mice with SRBCs provides antigen for anti-Sm B cell activation and activation of functional cognate T cells. We find that anti-Sm B cells from germinal centers in response to SRBC immunization, but fail to generate splenic or bone marrow plasma cells. Secondary, immunization shows the absence of memory B cell formation. BCR and CD40 signaling appears normal in anti-Sm B cells with the exception of an Akt signal by CD40. Our data suggest that Akt activation by CD40 signaling controls the formation of plasma cells and memory B cells by autoreactive B cells of the type activated in murine and human SLE. Experiments are underway to test this possibility." @default.
- W44560851 created "2016-06-24" @default.
- W44560851 creator A5003676871 @default.
- W44560851 creator A5046385299 @default.
- W44560851 creator A5047090777 @default.
- W44560851 date "2013-05-01" @default.
- W44560851 modified "2023-09-24" @default.
- W44560851 title "Akt activation by CD40 controls plasma cell and memory B cell differentiation but not germinal center formation by autoreactive B cells (P4032)" @default.
- W44560851 doi "https://doi.org/10.4049/jimmunol.190.supp.44.1" @default.
- W44560851 hasPublicationYear "2013" @default.
- W44560851 type Work @default.
- W44560851 sameAs 44560851 @default.
- W44560851 citedByCount "0" @default.
- W44560851 crossrefType "journal-article" @default.
- W44560851 hasAuthorship W44560851A5003676871 @default.
- W44560851 hasAuthorship W44560851A5046385299 @default.
- W44560851 hasAuthorship W44560851A5047090777 @default.
- W44560851 hasConcept C145558887 @default.
- W44560851 hasConcept C147483822 @default.
- W44560851 hasConcept C154317977 @default.
- W44560851 hasConcept C159654299 @default.
- W44560851 hasConcept C200180986 @default.
- W44560851 hasConcept C202751555 @default.
- W44560851 hasConcept C203014093 @default.
- W44560851 hasConcept C2776090121 @default.
- W44560851 hasConcept C2776396001 @default.
- W44560851 hasConcept C2778453870 @default.
- W44560851 hasConcept C2779359726 @default.
- W44560851 hasConcept C2780007613 @default.
- W44560851 hasConcept C39347974 @default.
- W44560851 hasConcept C55493867 @default.
- W44560851 hasConcept C67662055 @default.
- W44560851 hasConcept C86803240 @default.
- W44560851 hasConcept C8891405 @default.
- W44560851 hasConcept C95444343 @default.
- W44560851 hasConcept C96926380 @default.
- W44560851 hasConceptScore W44560851C145558887 @default.
- W44560851 hasConceptScore W44560851C147483822 @default.
- W44560851 hasConceptScore W44560851C154317977 @default.
- W44560851 hasConceptScore W44560851C159654299 @default.
- W44560851 hasConceptScore W44560851C200180986 @default.
- W44560851 hasConceptScore W44560851C202751555 @default.
- W44560851 hasConceptScore W44560851C203014093 @default.
- W44560851 hasConceptScore W44560851C2776090121 @default.
- W44560851 hasConceptScore W44560851C2776396001 @default.
- W44560851 hasConceptScore W44560851C2778453870 @default.
- W44560851 hasConceptScore W44560851C2779359726 @default.
- W44560851 hasConceptScore W44560851C2780007613 @default.
- W44560851 hasConceptScore W44560851C39347974 @default.
- W44560851 hasConceptScore W44560851C55493867 @default.
- W44560851 hasConceptScore W44560851C67662055 @default.
- W44560851 hasConceptScore W44560851C86803240 @default.
- W44560851 hasConceptScore W44560851C8891405 @default.
- W44560851 hasConceptScore W44560851C95444343 @default.
- W44560851 hasConceptScore W44560851C96926380 @default.
- W44560851 hasIssue "1_Supplement" @default.
- W44560851 hasLocation W445608511 @default.
- W44560851 hasOpenAccess W44560851 @default.
- W44560851 hasPrimaryLocation W445608511 @default.
- W44560851 hasRelatedWork W1749305630 @default.
- W44560851 hasRelatedWork W1965286634 @default.
- W44560851 hasRelatedWork W2031365470 @default.
- W44560851 hasRelatedWork W2041664710 @default.
- W44560851 hasRelatedWork W2409393912 @default.
- W44560851 hasRelatedWork W2582876455 @default.
- W44560851 hasRelatedWork W37541183 @default.
- W44560851 hasRelatedWork W4313356390 @default.
- W44560851 hasRelatedWork W4366590582 @default.
- W44560851 hasRelatedWork W44560851 @default.
- W44560851 hasVolume "190" @default.
- W44560851 isParatext "false" @default.
- W44560851 isRetracted "false" @default.
- W44560851 magId "44560851" @default.
- W44560851 workType "article" @default.