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- W44566586 abstract "The stem cell concept and asymmetric cell division are best understood in the hematopoietic system. Hematopoietic malignancies resemble many of the known normal mature hematopoietic lineages that originate from stem cells. Leukemias in particular, were shown to arise from leukemic stem cells. General characteristics of stem cells such as self-renewal, self-protection and proliferative quiescence clearly point toward the need for targeting leukemia stem cells in order to improve cure rates and to prevent relapse of this disease. However, leukemia stem cells share many stemness factors with hematopoietic stem cells, and owing to the inherent heterogeneity of leukemias, each subtype might have distinct stem cells. The successful targeting of leukemia stem cells will therefore require the careful consideration of these issues. This chapter gives an overview over leukemia stem cells and highlights pathways and disease specific markers that provide therapeutic targets. Agents that are under development or approved for cancer treatment and could target leukemia stem cells, are also reviewed.Key WordsALDH1DisulfiramSide populationBCRPPgpTelomeraseTelomeresArsenic trioxideBCR-ABLImatinibCD34CD38Clonogenic assay" @default.
- W44566586 created "2016-06-24" @default.
- W44566586 creator A5006790110 @default.
- W44566586 date "2009-01-01" @default.
- W44566586 modified "2023-09-27" @default.
- W44566586 title "Targeting Leukemic Stem Cells" @default.
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- W44566586 doi "https://doi.org/10.1007/978-1-60327-933-8_21" @default.
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