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- W44581377 abstract "Septic shock, especially due to gram-negative infection, continues to be an increasingly serious clinical problem carrying high mortality rate despite significant advances in antimicrobial therapeutics [1]. Moreover, this treatment has little effect on endotoxin (LPS), and may even promote the release of LPS from bacteria [2]. Release of LPS or other bacterial debris activate various humoral and cellular cascades which result in an effective defense against infection [3]. In many cases, however, this response becomes exaggerated causing tissue damage [4, 5]. These host defense systems include complement, kinin and clotting cascades with activation of macrophages and various leukocytes [3]. These cells, in turn, release several potent mediators." @default.
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- W44581377 date "1992-01-01" @default.
- W44581377 modified "2023-09-23" @default.
- W44581377 title "Platelet Activating Factor: Rationale for the Use of PAF-Antagonists in Sepsis" @default.
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- W44581377 doi "https://doi.org/10.1007/978-3-642-84827-8_27" @default.
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