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- W44581492 abstract "Cutaneous aging represents a complex situation in which at least two independent factors-innate aging and solar exposure--contribute to the development of degenerative changes in the dermis. The biochemical and ultrastructural evidence reviewed in this article indicates that reduced collagen deposition, as a result of diminished collagen biosynthesis and reduced proliferative capacity of the fibroblasts, could explain the development of dermal atrophy and would relate to poor wound healing in the elderly. At the same time, perturbations in the supramolecular organization of the elastic fiber network lead to alterations in the mechanical properties of the skin, as manifested by loose and sagging skin with reduced resilience and elasticity." @default.
- W44581492 created "2016-06-24" @default.
- W44581492 creator A5032533037 @default.
- W44581492 date "1986-07-01" @default.
- W44581492 modified "2023-09-23" @default.
- W44581492 title "Connective Tissue Biochemistry of the Aging Dermis" @default.
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- W44581492 doi "https://doi.org/10.1016/s0733-8635(18)30806-4" @default.
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