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- W44680413 abstract "We have shown that GABAA, NMDA, and AT1 receptors in the hypothalamic median preoptic nucleus (MnPO) contribute to hemodynamic response variability to cocaine in Sprague-Dawley rats. These receptors may also contribute to differences in response pattern in two unrelated strains of rats. We named Dahl salt-sensitive/Mcw (DS) rats cardiac responders since they exhibit an increase in arterial pressure (AP) following cocaine that was due entirely to an increase in cardiac output (CO). We called Brown-Norway/Mcw (BN) rats vascular responders since they exhibit a similar, sustained increase in AP following cocaine that was due entirely to an increase in systemic vascular resistance (SVR). Microinjection of either the GABAA agonist muscimol (80 pmol/100 nl) or the NMDA receptor antagonist MK-801 (dizocilpine, 20 nmol) into the MnPO attenuated the decrease in CO and the increase in SVR in BN after cocaine without affecting the responses in DS. Injection of the AT1 receptor antagonist losartan (20 ng) into the MnPO prevented hemodynamic response differences to cocaine in DS and BN. Microinjection of l-NAME (4 nmol) into the MnPO did not alter responses to cocaine in DS or BN. These results suggest that MnPO GABAA, NMDA, and AT1 receptors participate in producing the vascular response to cocaine in BN. Supported by USPHS DA017371, GM008306, and a predoctoral fellowship from the American Heart Association, Heartland Affiliate." @default.
- W44680413 created "2016-06-24" @default.
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- W44680413 date "2008-03-01" @default.
- W44680413 modified "2023-10-17" @default.
- W44680413 title "AT1, NMDA, and GABAA receptors in the median preoptic nucleus mediate greater vascular responses in Brown‐Norway/Mcw rats compared to Dahl salt‐sensitive/Mcw rats" @default.
- W44680413 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1170.8" @default.
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