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• W447356175 abstract "Background: In hernia repair, implantation of surgical meshes is a common procedure to increase abdominal wall stability, resulting in significantly reduced recurrence rates when compared to conventional suture closures. However, mesh implantation is known to be associated with the risk of bacterial infection. Thus, the aim of the present study was to analyze in vivo, whether the interaction of bacteria with the microvascular endothelium is increased in direct vicinity of an implanted mesh under physiological and inflammatory conditions. Materials and Methods: Ultrapro meshes were implanted into the dorsal skinfold chamber of 19 Syrian golden hamsters. After 12 days, 109 fluorescein isothiocyanate (FITC) labeled staphylococci were injected via a carotid catheter in 8 animals. Subsequently, we analyzed leukocyte-endothelial cell interaction, microhemodynamics and bacterial binding in venules located in direct vicinity to the mesh implants (border zone) or in distant control tissue under baseline conditions as well as after TNF-α-induced inflammation (topical application for 30 min, 2000 U dissolved in 100 μl PBS) using intravital fluorescence microscopy. The results were compared to a group of 11 animals, which did not receive any bacteria. Results: Under baseline conditions, leukocyte-endothelial cell interaction and bacterial adherence was not increased due to the implanted biomaterial, as indicated by a comparable number of adherent leukocytes (58 ± 5 mm−2) and bacteria (71 ± 18 mm−2) in venules of the mesh border zone and distant control tissue (59 ± 22 mm−2 and 46 ± 10 mm−2). TNF-α- induced inflammation significantly increased the numbers of adherent leukocytes (453 ± 50 mm−2, p < 0.05) and bacteria (175 ± 20 mm−2, p < 0.05) in venules located in direct vicinity to the mesh. However, there was again no difference to distant control tissue (619 ± 69 mm−2 and 214 ± 18 mm−2). Comparable results for the leukocyte-endothelial cell interaction were found in animals, which did not receive a bacterial injection, indicating that circulating bacteria do not affect leukocyte recruitment to the site of mesh implantation. Conclusion: Our study shows that implanted Ultrapro meshes do not affect the interaction of Staphylococcus aureus with the microvascular endothelium under physiological conditions or TNF-α-induced inflammation. This indicates that the implanted biomaterial itself is not a trigger for an increased bacterial adherence to the endothelium and therefore cannot be considered as the primary cause for bacterial mesh infection. Besides, this study demonstrates that circulating bacteria do not increase leukocyte recruitment to the site of mesh implantation." @default.
• W447356175 created "2016-06-24" @default.
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• W447356175 date "2008-01-01" @default.
• W447356175 modified "2023-09-23" @default.
• W447356175 title "Prolene-Monocryl-Komposite-Netze induzieren weder eine Interaktion von Staphylokokkus aureus mit dem Gefäßendothel, noch begünstigen sie eine leukozytäre Entzündungsreaktion" @default.
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• W447356175 doi "https://doi.org/10.1007/978-3-540-78833-1_88" @default.
• W447356175 hasPublicationYear "2008" @default.
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