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- W44868800 abstract "Abstract Immunosenescence is a public health concern. This study was to characterize the peripheral immune system in rhesus macaques of varying ages. Flow cytometry and multiplex cytokine levels were evaluated in blood from 35 monkeys (3.2-20 years old). Linear regression was used to define statistically significant changes (i.e. P<0.05) with age. Significant declines were observed in numbers of neutrophils, eosinophils, basophils, and lymphocytes in blood with increasing age. No changes in numbers of monocytes, dendritic cells (DC), RBCs, or platelets were noted. Among lymphocytes, B cell numbers declined while NK cells and T cells were unchanged with increasing age. Within the T cell population, however, significant declines in naive CD4+ and CD8+ T cells, and γδ+T cells were seen with increasing age, whereas the number of CD8+ effector-memory T cells increased with age. Numbers of DCs did not change with advancing age, but the turnover rate of pDCs was higher in the 18-20 year-old group compared to younger groups. Of the cytokines tested in plasma using the Milliplex non-human primate cytokine (23-mer) kit, TNF-α, IL-2, MCP-1, sCD40L, TGF-α, VEGF, and IL-18 levels significantly increased with increasing age whereas IL-5 was the only cytokine tested that decreased with increasing age. These early results provide a basis to further characterize immunosenescence in a non-human primate model." @default.
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- W44868800 date "2011-04-01" @default.
- W44868800 modified "2023-09-30" @default.
- W44868800 title "Immunologic profile changes associated with aging in rhesus macaques (104.2)" @default.
- W44868800 doi "https://doi.org/10.4049/jimmunol.186.supp.104.2" @default.
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