Matches in SemOpenAlex for { <https://semopenalex.org/work/W44940103> ?p ?o ?g. }
- W44940103 abstract "Morphine is routinely used as an analgesic for acute and chronic pain, often in people at greater risk for infection, in spite of the fact that morphine suppresses immune function. Recent studies indicate that morphine alters antigen-presenting gene expression, including genes encoding for MHC-II. As alterations of antigen presentation directly affect immune cell activation, proliferation, and survival, both innate and acquired immune responses may be attenuated after morphine treatment or withdrawal. Few studies have examined the effects of morphine on antigen presentation. Therefore, these studies sought to characterize the effect of morphine on MHC-II expression. Morphine (10 mg/kg, 2 hours) was found to significantly reduce basal and IL-4 induced MHC-II expression on circulating B lymphocytes. This effect appeared to be mediated through centrally located mu-opioid receptors as central injection of DAMGO mimicked the morphine-induced suppression of MHC-II while it was blocked by central pretreatment with naltrexone or CTOP. Since morphine activates the HPA axis, the role of corticosterone in mediating these effects was examined. Corticosterone decreased basal MHC-II expression on naive leukocytes by 88% and completely" @default.
- W44940103 created "2016-06-24" @default.
- W44940103 creator A5031765499 @default.
- W44940103 date "2008-01-01" @default.
- W44940103 modified "2023-09-23" @default.
- W44940103 title "Morphine activation of stress pathways alters peripheral immune cell signaling" @default.
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