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- W45033986 abstract "In order to maintain their unlimited capacity to divide, stem cells require controlled temporal and spatial protein expression. The Musashi family of RNA-binding proteins have been shown to exhibit this necessary translational control through both repression and activation in order to regulate multiple stem cell populations. This chapter looks in depth at the initial discovery and characterisation of Musashi in the model organism Drosophila, and its subsequent emergence as a master regulator in a number of stem cell populations. Furthermore the unique roles for mammalian Musashi-1 and Musashi-2 in different stem cell types are correlated with the perceived diagnostic power of Musashi expression in specific stem cell derived oncologies. In particular the potential role for Musashi in the identification and treatment of human cancer is considered, with a focus on the role of Musashi-2 in leukaemia. Finally, the manipulation of Musashi expression is proposed as a potential avenue towards the targeted treatment of specific aggressive stem cell cancers." @default.
- W45033986 created "2016-06-24" @default.
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- W45033986 date "2013-01-01" @default.
- W45033986 modified "2023-09-27" @default.
- W45033986 title "The Musashi Family of RNA Binding Proteins: Master Regulators of Multiple Stem Cell Populations" @default.
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- W45033986 cites W1528342365 @default.
- W45033986 cites W1607062179 @default.
- W45033986 cites W1965409148 @default.
- W45033986 cites W1969589143 @default.
- W45033986 cites W1975822702 @default.
- W45033986 cites W1978124642 @default.
- W45033986 cites W1979661412 @default.
- W45033986 cites W1980867815 @default.
- W45033986 cites W1981592095 @default.
- W45033986 cites W1983344050 @default.
- W45033986 cites W1983479039 @default.
- W45033986 cites W1984805978 @default.
- W45033986 cites W1985120655 @default.
- W45033986 cites W1987684058 @default.
- W45033986 cites W1990648173 @default.
- W45033986 cites W1990877484 @default.
- W45033986 cites W1992106179 @default.
- W45033986 cites W1992282510 @default.
- W45033986 cites W1999920074 @default.
- W45033986 cites W2002708668 @default.
- W45033986 cites W2002715625 @default.
- W45033986 cites W2003787418 @default.
- W45033986 cites W2005361397 @default.
- W45033986 cites W2007360825 @default.
- W45033986 cites W2007822205 @default.
- W45033986 cites W2009606787 @default.
- W45033986 cites W2009947065 @default.
- W45033986 cites W2012608371 @default.
- W45033986 cites W2018657730 @default.
- W45033986 cites W2018995141 @default.
- W45033986 cites W2021312689 @default.
- W45033986 cites W2021429236 @default.
- W45033986 cites W2024169390 @default.
- W45033986 cites W2026611875 @default.
- W45033986 cites W2029536633 @default.
- W45033986 cites W2033056030 @default.
- W45033986 cites W2041990118 @default.
- W45033986 cites W2047265063 @default.
- W45033986 cites W2052934458 @default.
- W45033986 cites W2055624537 @default.
- W45033986 cites W2056936400 @default.
- W45033986 cites W2058572671 @default.
- W45033986 cites W2058903496 @default.
- W45033986 cites W2062059217 @default.
- W45033986 cites W2062852790 @default.
- W45033986 cites W2064579758 @default.
- W45033986 cites W2065387006 @default.
- W45033986 cites W2067700202 @default.
- W45033986 cites W2069584695 @default.
- W45033986 cites W2071331346 @default.
- W45033986 cites W2073482385 @default.
- W45033986 cites W2075542228 @default.
- W45033986 cites W2077927052 @default.
- W45033986 cites W2084316080 @default.
- W45033986 cites W2086169503 @default.
- W45033986 cites W2087589198 @default.
- W45033986 cites W2092642151 @default.
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- W45033986 cites W2111230271 @default.
- W45033986 cites W2126873973 @default.
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- W45033986 cites W2140770375 @default.
- W45033986 cites W2141527732 @default.
- W45033986 cites W2147918331 @default.
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- W45033986 cites W2152127811 @default.
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- W45033986 doi "https://doi.org/10.1007/978-94-007-6621-1_13" @default.
- W45033986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23696360" @default.
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