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- W45083469 abstract "The intestinal epithelium can be separated in two main compartments: the crypt and the villus, each with its own unique cellular composition. Crypts contain undifferentiated cells as their chief component, but also harbor enteroendocrine cells, Paneth cells, and goblet cells. It is generally accepted that the undifferentiated crypt cells act as the progenitor cells from which all cell types of intestinal epithelial cells originate. With the striking exception of Paneth cells, which remain at the crypt base, other crypt cell types appear to migrate toward the villus surface. During this migration, particularly in the upper portion of the crypt, many undifferentiated crypt cells acquire structural and functional characteristics of villus absorptive cells. The villus absorptive cell is the major cell type on the villus compartment, but goblet and enteroendocrine cells are also present. The function of one cell type is different from that of another, but at least three cell types share common features: they are capable of secreting regulatory peptides. These cell types include the enteroendocrine, Paneth, and goblet cells. The enteroendocrine cells have been subclassified on the basis of their peptide contents as revealed by immunohistochemistry. At least 16 different endocrine cell types have been identified. However, they constitute a small minority of the epithelial cells lining the gut wall. Enterochromaffin (EC) cells are located both in the epithelium of the small intestine and in the colonic epithelium. There is a consensus that EC cells constitute the majority of endocrine cells in the colon. One of the products stored in the secretory granules of these cells is 5-hydroxytryptamine (5-HT). Recent studies indicate that EC cells also synthesize guanylin, which once released into the lumen, participates in water and electrolyte homeostasis." @default.
- W45083469 created "2016-06-24" @default.
- W45083469 creator A5090584792 @default.
- W45083469 date "1999-01-01" @default.
- W45083469 modified "2023-09-25" @default.
- W45083469 title "Peptide Release from the Upper Small Intestine" @default.
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- W45083469 doi "https://doi.org/10.1007/978-1-59259-695-9_14" @default.
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