Matches in SemOpenAlex for { <https://semopenalex.org/work/W45096280> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W45096280 endingPage "30" @default.
- W45096280 startingPage "25" @default.
- W45096280 abstract "The potential role of complement activation and the membrane attack complex in the pathogenesis of Graves' disease and Hashimoto's thyroiditis has been investigated by measuring serum concentrations of the C1r-C1s-C1 inhibitor complex (C1/C1-inh) and the terminal complement complex (TCC), and by studying the binding to thyroid tissue of monoclonal and polyclonal antibodies against TCC neoantigens. Serum C1/C1-inh and TCC concentrations were significantly increased in 29 patients with untreated Graves' disease compared with 47 healthy subjects (P less than 0.001 for both), and decreased significantly after carbimazole treatment in 18 of these patients for whom post-treatment samples were available (P less than 0.01 and P less than 0.02, respectively). The serum TCC concentration, but not that of C1/C1-inh, was also significantly increased in 15 patients with Hashimoto's thyroiditis compared with the 47 healthy subjects (P less than 0.001). TCCs were identified by immunohistochemical staining around the thyroid follicles in thyroidectomy specimens from patients with Graves' disease (six out of six) and Hashimoto's thyroiditis (two out of two); normal thyroid tissue from two subjects showed no staining. These results suggest a role for complement, in particular the membrane attack complex in the pathogenesis of autoimmune thyroid disease." @default.
- W45096280 created "2016-06-24" @default.
- W45096280 creator A5004757942 @default.
- W45096280 creator A5032034922 @default.
- W45096280 creator A5036234034 @default.
- W45096280 creator A5084376700 @default.
- W45096280 date "1989-07-01" @default.
- W45096280 modified "2023-09-23" @default.
- W45096280 title "Terminal complement complexes and C1/C1 inhibitor complexes in autoimmune thyroid disease." @default.
- W45096280 cites W1209169208 @default.
- W45096280 cites W160726163 @default.
- W45096280 cites W193776670 @default.
- W45096280 cites W1989728031 @default.
- W45096280 cites W1993799487 @default.
- W45096280 cites W1999277930 @default.
- W45096280 cites W2018276288 @default.
- W45096280 cites W2024399892 @default.
- W45096280 cites W2030784227 @default.
- W45096280 cites W2036533783 @default.
- W45096280 cites W2043072637 @default.
- W45096280 cites W2049754499 @default.
- W45096280 cites W2055345403 @default.
- W45096280 cites W2071052998 @default.
- W45096280 cites W2073346397 @default.
- W45096280 cites W2073699187 @default.
- W45096280 cites W2094964489 @default.
- W45096280 cites W2124314287 @default.
- W45096280 cites W2129446088 @default.
- W45096280 cites W2339788578 @default.
- W45096280 cites W2400598117 @default.
- W45096280 cites W2411467374 @default.
- W45096280 cites W2413317756 @default.
- W45096280 cites W2416833242 @default.
- W45096280 cites W1579429254 @default.
- W45096280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1541918" @default.
- W45096280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2766576" @default.
- W45096280 hasPublicationYear "1989" @default.
- W45096280 type Work @default.
- W45096280 sameAs 45096280 @default.
- W45096280 citedByCount "15" @default.
- W45096280 countsByYear W450962802016 @default.
- W45096280 countsByYear W450962802017 @default.
- W45096280 countsByYear W450962802021 @default.
- W45096280 crossrefType "journal-article" @default.
- W45096280 hasAuthorship W45096280A5004757942 @default.
- W45096280 hasAuthorship W45096280A5032034922 @default.
- W45096280 hasAuthorship W45096280A5036234034 @default.
- W45096280 hasAuthorship W45096280A5084376700 @default.
- W45096280 hasConcept C111684460 @default.
- W45096280 hasConcept C126322002 @default.
- W45096280 hasConcept C134018914 @default.
- W45096280 hasConcept C142724271 @default.
- W45096280 hasConcept C159654299 @default.
- W45096280 hasConcept C203014093 @default.
- W45096280 hasConcept C2776652619 @default.
- W45096280 hasConcept C2778696486 @default.
- W45096280 hasConcept C2779075594 @default.
- W45096280 hasConcept C2779134260 @default.
- W45096280 hasConcept C2780176905 @default.
- W45096280 hasConcept C2780942790 @default.
- W45096280 hasConcept C526584372 @default.
- W45096280 hasConcept C71924100 @default.
- W45096280 hasConceptScore W45096280C111684460 @default.
- W45096280 hasConceptScore W45096280C126322002 @default.
- W45096280 hasConceptScore W45096280C134018914 @default.
- W45096280 hasConceptScore W45096280C142724271 @default.
- W45096280 hasConceptScore W45096280C159654299 @default.
- W45096280 hasConceptScore W45096280C203014093 @default.
- W45096280 hasConceptScore W45096280C2776652619 @default.
- W45096280 hasConceptScore W45096280C2778696486 @default.
- W45096280 hasConceptScore W45096280C2779075594 @default.
- W45096280 hasConceptScore W45096280C2779134260 @default.
- W45096280 hasConceptScore W45096280C2780176905 @default.
- W45096280 hasConceptScore W45096280C2780942790 @default.
- W45096280 hasConceptScore W45096280C526584372 @default.
- W45096280 hasConceptScore W45096280C71924100 @default.
- W45096280 hasIssue "1" @default.
- W45096280 hasLocation W450962801 @default.
- W45096280 hasOpenAccess W45096280 @default.
- W45096280 hasPrimaryLocation W450962801 @default.
- W45096280 hasRelatedWork W1992999667 @default.
- W45096280 hasRelatedWork W2030547574 @default.
- W45096280 hasRelatedWork W2033506857 @default.
- W45096280 hasRelatedWork W2046220142 @default.
- W45096280 hasRelatedWork W2050646365 @default.
- W45096280 hasRelatedWork W2089052917 @default.
- W45096280 hasRelatedWork W24396818 @default.
- W45096280 hasRelatedWork W2811327043 @default.
- W45096280 hasRelatedWork W72427302 @default.
- W45096280 hasRelatedWork W96096646 @default.
- W45096280 hasVolume "77" @default.
- W45096280 isParatext "false" @default.
- W45096280 isRetracted "false" @default.
- W45096280 magId "45096280" @default.
- W45096280 workType "article" @default.