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- W45127769 abstract "Publisher Summary Intraepithelial lymphocytes (IEL) of the small and large intestine comprise a specialized immune compartment presumably geared toward surveillance of the intestinal epithelial layer. One of the most intriguing aspects of IEL biology is the role of the thymus in their development. This chapter utilizes neonatal thymectomy and thymus grafting as a means of studying the role of the thymus in IEL development. In the case of thymus grafting, it is tested whether the thymus is capable of producing IEL, rather than asking whether removal of the thymus affects IEL maturation. Overall, the results demonstrate that the thymus plays a dual role in IEL development: as a source of IEL precursors and as a source of as yet unidentified factors that aid IEL maturation." @default.
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- W45127769 date "1996-01-01" @default.
- W45127769 modified "2023-09-26" @default.
- W45127769 title "Development of Intestinal Intraepithelial Lymphocytes" @default.
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- W45127769 doi "https://doi.org/10.1016/b978-012394330-9/50017-x" @default.
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