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- W45244162 abstract "An elevation of cytoplasmic free calcium ion concentration ([Ca2+]i)1 serves to couple the interaction of many hormones and neurotransmitters with plasma membrane receptors to the stimulation of a variety of cellular processes. This chapter discusses the intracellular events that couple thyrotropin-releasing hormone (TRH)-receptor interaction to the elevation of [Ca2+]I in GH3 cells. In order to understand the molecular mechanisms that mediate the elevation of [Ca2+]i, it is important to identify both the potential mediators of this effect and the pool of calcium that contribute to the increase in [Ca2+]i. For the investigations, GH3 cells are utilized, a cloned cell line that is widely employed as a model to study the physiology of pituitary mammotropic cells. The chapter presents evidence from the studies in GH3 cells—(1) TRH stimulates an elevation of [Ca2+]i in part by mobilizing calcium from an intracellular, nonmitochondrial pool; (2) TRH stimulates the rapid, phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), a minor plasma membrane phospholipid, to yield inositol 1,4,5-trisphosphate (InsP3); (3) InsP3 is capable of rapidly mobilizing calcium from an intracellular, non mitochondrial pool. Based on these observations, the chapter explains that TRH stimulates the hydrolysis of PtdIns(4,5)P2 to InsP3 that, in turn, mobilizes calcium from a nonmitochondrial pool leading to elevation of [Ca2+]i then to activation of exocytosis and to stimulated prolactin secretion." @default.
- W45244162 created "2016-06-24" @default.
- W45244162 creator A5005079343 @default.
- W45244162 date "1985-01-01" @default.
- W45244162 modified "2023-09-26" @default.
- W45244162 title "Thyrotropin-Releasing Hormone Action: Mechanism of Calcium-Mediated Stimulation of Prolactin Secretion" @default.
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- W45244162 doi "https://doi.org/10.1016/b978-0-12-571141-8.50019-6" @default.
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