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- W45280529 abstract "The development of metastatic capacity in a tumor is a multistep process characterized both by the loss of normal behavior and by the acquisition of new properties (Fidler and Hart 1982; Hart and Saini 1992). The identification of molecules which are newly expressed, altered or lost during this process can lead to an understanding of the molecular basis of tumor progression and metastasis formation and can also lead to the development of diagnostic and therapeutic tools. We have used monoclonal antibodies to define, in human melanoma, molecules that change their expression patterns in concert with the appearance of parameters known to be predictive for the occurrence of metastatic disease (Clark et al. 1984; Herlyn et al. 1987; Johnson 1995). Using this approach the 113kDa cell surface glycoprotein MUC18 was identified as a human melanoma associated antigen that increases in expression as tumors increase in vertical thickness and begin to acquire metastatic potential (Lehmann et al. 1987)." @default.
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- W45280529 date "1996-01-01" @default.
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- W45280529 title "MUC18: A Cell Adhesion Molecule with a Potential Role in Tumor Growth and Tumor Cell Dissemination" @default.
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- W45280529 doi "https://doi.org/10.1007/978-3-642-61107-0_7" @default.
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