Matches in SemOpenAlex for { <https://semopenalex.org/work/W45319957> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W45319957 endingPage "5" @default.
- W45319957 startingPage "1" @default.
- W45319957 abstract "The theory of evolution of tumor cell population has been established for nearly 40 years. It was widely accepted for research and clinical anti-tumor treatment. Recently, it was suggested that cancer stem cells are the unit of evolution. Considering recent advances on genesis of tumor and leukemia with ecological and evolutionary views, this article reviews origin and evolution of leukemia stem cells. Over the last few years, clinical and experimental data suggest there are two paths for the origin of leukemia stem cells: from a transformed hematopoietic stem cell or progenitor. The mechanisms of leukemia stem cell formation and clonal evolution were elucidated. Sub-clonal mutations and clonal architectures in leukemia were studied and a mosaic evolution pattern is described. Random evolution or non-inherited mutations of leukemia cells would accelerate the progression of malignant disease. Finally, the mosaic or network mechanism for leukemogenesis is also discussed." @default.
- W45319957 created "2016-06-24" @default.
- W45319957 creator A5017005334 @default.
- W45319957 creator A5036680742 @default.
- W45319957 creator A5052076760 @default.
- W45319957 creator A5060867127 @default.
- W45319957 creator A5081950834 @default.
- W45319957 date "2015-02-01" @default.
- W45319957 modified "2023-10-18" @default.
- W45319957 title "[Clonal evolution in leukemia]." @default.
- W45319957 doi "https://doi.org/10.7534/j.issn.1009-2137.2015.01.001" @default.
- W45319957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25687036" @default.
- W45319957 hasPublicationYear "2015" @default.
- W45319957 type Work @default.
- W45319957 sameAs 45319957 @default.
- W45319957 citedByCount "0" @default.
- W45319957 crossrefType "journal-article" @default.
- W45319957 hasAuthorship W45319957A5017005334 @default.
- W45319957 hasAuthorship W45319957A5036680742 @default.
- W45319957 hasAuthorship W45319957A5052076760 @default.
- W45319957 hasAuthorship W45319957A5060867127 @default.
- W45319957 hasAuthorship W45319957A5081950834 @default.
- W45319957 hasConcept C109159458 @default.
- W45319957 hasConcept C113968399 @default.
- W45319957 hasConcept C121608353 @default.
- W45319957 hasConcept C201750760 @default.
- W45319957 hasConcept C2778461978 @default.
- W45319957 hasConcept C28328180 @default.
- W45319957 hasConcept C502942594 @default.
- W45319957 hasConcept C54355233 @default.
- W45319957 hasConcept C55427017 @default.
- W45319957 hasConcept C78458016 @default.
- W45319957 hasConcept C86803240 @default.
- W45319957 hasConceptScore W45319957C109159458 @default.
- W45319957 hasConceptScore W45319957C113968399 @default.
- W45319957 hasConceptScore W45319957C121608353 @default.
- W45319957 hasConceptScore W45319957C201750760 @default.
- W45319957 hasConceptScore W45319957C2778461978 @default.
- W45319957 hasConceptScore W45319957C28328180 @default.
- W45319957 hasConceptScore W45319957C502942594 @default.
- W45319957 hasConceptScore W45319957C54355233 @default.
- W45319957 hasConceptScore W45319957C55427017 @default.
- W45319957 hasConceptScore W45319957C78458016 @default.
- W45319957 hasConceptScore W45319957C86803240 @default.
- W45319957 hasIssue "1" @default.
- W45319957 hasLocation W453199571 @default.
- W45319957 hasOpenAccess W45319957 @default.
- W45319957 hasPrimaryLocation W453199571 @default.
- W45319957 hasRelatedWork W1976203623 @default.
- W45319957 hasRelatedWork W1986205398 @default.
- W45319957 hasRelatedWork W2050237143 @default.
- W45319957 hasRelatedWork W2059069616 @default.
- W45319957 hasRelatedWork W2103054294 @default.
- W45319957 hasRelatedWork W2113080127 @default.
- W45319957 hasRelatedWork W2129857146 @default.
- W45319957 hasRelatedWork W2983333159 @default.
- W45319957 hasRelatedWork W4210379329 @default.
- W45319957 hasRelatedWork W44566586 @default.
- W45319957 hasVolume "23" @default.
- W45319957 isParatext "false" @default.
- W45319957 isRetracted "false" @default.
- W45319957 magId "45319957" @default.
- W45319957 workType "article" @default.