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- W45355385 abstract "Cytochromes P450 (CYP) from families CYP1/2/3 are involved in xenobiotic detoxification and are regulated by numerous agents including xenobiotics, plant and fungal toxins, bile salts, etc. Nuclear receptors PXR (pregnane X receptor, NR1I3) and CAR (constitutive androstane receptor, NR1I2) control the expression of distinct but overlapping arrays of genes including the CYP2/3 families. These receptors are involved in a tangle of regulatory networks including those pathways controlling vitamin D and cholesterol/bile salt homeostasis. They are expressed under the control of the glucocorticoid receptor and are inhibited by the short heterodimer partner (SHP). The crosstalk between both PXR and CAR and other nuclear receptors allows for the establishing and prediction of functional interferences between the detoxification and other signaling and metabolic pathways. These interferences provide new clues for the interpretation of xenobiotic adverse effects, such as bone demineralization, and for understanding how physiopathological factors, such as biliary salts or inflammation and infections, affect an organism’s ability to detoxify xenobiotics." @default.
- W45355385 created "2016-06-24" @default.
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- W45355385 date "2004-01-01" @default.
- W45355385 modified "2023-10-17" @default.
- W45355385 title "Regulation of Xenobiotic Detoxification by PXR, CAR, GR, VDR and SHP Receptors: Consequences in Physiology" @default.
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