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- W45413626 abstract "A modified release bi-layered tablet of melatonin incorporating a fast release fraction consisting of melatonin-beta-cyclodextrin inclusion complex and a slow release fraction containing melatonin in HPMC K15M and Carbopol 971 P matrices was prepared. The formulation developed showed an initial burst followed by a near zero order release pattern for a period of 8 h. The drug content, physical characteristics and the release profile were unaffected after 3 months of an accelerated stability study at 40 degrees C and 75% relative humidity." @default.
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- W45413626 date "2003-09-01" @default.
- W45413626 modified "2023-09-23" @default.
- W45413626 title "Modified release bi-layered tablet of melatonin using beta-cyclodextrin." @default.
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