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- W45441489 abstract "Microbial DNA containing unmethylated CpG dinucleotides (Irnmunostimulatory sequence [ISS] DNA, or CpG motifs) act upon cells of the innate immune system such as phagocytes (macrophages and dendritic cells [DC]) and NK cells and upon B cells, promoting the expression of proinflammatory cytokines and surface molecules (1–4). They have little direct effect upon CD8+ and CD4+ T cells, yet animal models have shown that ISS-based vaccines promote two antigen-specific T cell responses: cytotoxic lymphocyte (CTL) activity and a Th1-type helper phenotype (5–8) (Fig. 1). This phenomenon has been observed with plasmid DNA vaccines (9), protein and synthetic ISS oligodeoxynucleotide (ISS-ODN) co-administration (6,10–12), and protein-ISS-ODN conjugate vaccines (13,14). Similar T-cell responses have been shown with distinct experimental antigens, including bacterial β-galactosidase (6), chicken ovalbumin (13), hepatitis B virus surface antigen (15), and human immunodeficiency virus gp 120 (14). Effective CTL and Th 1 priming has been observed with both intradermal (13,16) and intranasal (12) routes of immunization. Of note, priming of CTL activity with ISS-ODN and protein antigen, either coadministration or as conjugates, is independent of major histocompatibility complex (MHC) class II-restricted T helper activity, whereas priming by plasmid DNA vaccines is not (13)." @default.
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- W45441489 date "2002-01-01" @default.
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- W45441489 title "Cross-Priming of CD8 + T Cells by Immunostimulatory Sequence DNA" @default.
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