Matches in SemOpenAlex for { <https://semopenalex.org/work/W45486543> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W45486543 abstract "Surfactant protein-A (SP-A) interacts with pulmonary and epithelial defenses. Exposure to ozone (O3), a prototypal air pollutant, leads to tissue inflammation, and loss of epithelial integrity. Following O3 exposure SP-A levels may decrease within airway lining fluids and/or undergo structural modification, and epithelial permeability increases. To determine if SP-A is a key component of epithelial barrier function we exposed SP-A null, and WT mice to inhaled O3. Serum albumin levels in bronchoalveolar lavage fluid (BAL), an index of permeability, were significantly elevated at baseline and after O3 in SP-A null as compared to WT mice. BAL serum levels correlated with epithelial permeability in vivo as evidenced by paracellular clearance of a radiomarker (492 Da, hydrophilic) assessed directly by 2-D scintigraphy. When evaluated in humans (n=130) using a controlled laboratory exposure sensitivity to O3 was differential, with 26% of subjects exhibiting O3-induced increases in epithelial permeability at 20 h post-O3 as compared to filtered air. Stratified for ethnicity, Caucasian subjects with at least one copy of a minor allele of a common SP-A polymorphism, were found to be at more than 2x the risk to sustain loss of epithelial integrity after O3, as subjects homozygous for the major, wild-type allele. Summary these data show that functional SP-A enhances epithelial integrity and that a common polymorphism on SP-A 2 gene modulates risk of epithelial injury from ozone. Supported by NIH: ES016126 (JWH); AI081672 (WMF)." @default.
- W45486543 created "2016-06-24" @default.
- W45486543 creator A5014455913 @default.
- W45486543 creator A5023199330 @default.
- W45486543 creator A5033636135 @default.
- W45486543 creator A5067875096 @default.
- W45486543 creator A5083134200 @default.
- W45486543 date "2011-04-01" @default.
- W45486543 modified "2023-10-09" @default.
- W45486543 title "Surfactant protein‐A protects epithelial barrier function in mice and humans during exposure to ozone" @default.
- W45486543 doi "https://doi.org/10.1096/fasebj.25.1_supplement.1036.7" @default.
- W45486543 hasPublicationYear "2011" @default.
- W45486543 type Work @default.
- W45486543 sameAs 45486543 @default.
- W45486543 citedByCount "0" @default.
- W45486543 crossrefType "journal-article" @default.
- W45486543 hasAuthorship W45486543A5014455913 @default.
- W45486543 hasAuthorship W45486543A5023199330 @default.
- W45486543 hasAuthorship W45486543A5033636135 @default.
- W45486543 hasAuthorship W45486543A5067875096 @default.
- W45486543 hasAuthorship W45486543A5083134200 @default.
- W45486543 hasConcept C120882062 @default.
- W45486543 hasConcept C126322002 @default.
- W45486543 hasConcept C142724271 @default.
- W45486543 hasConcept C153911025 @default.
- W45486543 hasConcept C16685009 @default.
- W45486543 hasConcept C185592680 @default.
- W45486543 hasConcept C203014093 @default.
- W45486543 hasConcept C207001950 @default.
- W45486543 hasConcept C2776914184 @default.
- W45486543 hasConcept C2777714996 @default.
- W45486543 hasConcept C2777961210 @default.
- W45486543 hasConcept C41625074 @default.
- W45486543 hasConcept C51911345 @default.
- W45486543 hasConcept C529295009 @default.
- W45486543 hasConcept C54355233 @default.
- W45486543 hasConcept C55493867 @default.
- W45486543 hasConcept C60903277 @default.
- W45486543 hasConcept C71924100 @default.
- W45486543 hasConcept C86803240 @default.
- W45486543 hasConcept C95444343 @default.
- W45486543 hasConceptScore W45486543C120882062 @default.
- W45486543 hasConceptScore W45486543C126322002 @default.
- W45486543 hasConceptScore W45486543C142724271 @default.
- W45486543 hasConceptScore W45486543C153911025 @default.
- W45486543 hasConceptScore W45486543C16685009 @default.
- W45486543 hasConceptScore W45486543C185592680 @default.
- W45486543 hasConceptScore W45486543C203014093 @default.
- W45486543 hasConceptScore W45486543C207001950 @default.
- W45486543 hasConceptScore W45486543C2776914184 @default.
- W45486543 hasConceptScore W45486543C2777714996 @default.
- W45486543 hasConceptScore W45486543C2777961210 @default.
- W45486543 hasConceptScore W45486543C41625074 @default.
- W45486543 hasConceptScore W45486543C51911345 @default.
- W45486543 hasConceptScore W45486543C529295009 @default.
- W45486543 hasConceptScore W45486543C54355233 @default.
- W45486543 hasConceptScore W45486543C55493867 @default.
- W45486543 hasConceptScore W45486543C60903277 @default.
- W45486543 hasConceptScore W45486543C71924100 @default.
- W45486543 hasConceptScore W45486543C86803240 @default.
- W45486543 hasConceptScore W45486543C95444343 @default.
- W45486543 hasFunder F4320332161 @default.
- W45486543 hasIssue "S1" @default.
- W45486543 hasLocation W454865431 @default.
- W45486543 hasOpenAccess W45486543 @default.
- W45486543 hasPrimaryLocation W454865431 @default.
- W45486543 hasRelatedWork W1965647068 @default.
- W45486543 hasRelatedWork W2004920288 @default.
- W45486543 hasRelatedWork W2012501032 @default.
- W45486543 hasRelatedWork W2046876558 @default.
- W45486543 hasRelatedWork W2098828878 @default.
- W45486543 hasRelatedWork W2369056050 @default.
- W45486543 hasRelatedWork W2761173982 @default.
- W45486543 hasRelatedWork W2905245425 @default.
- W45486543 hasRelatedWork W3083815875 @default.
- W45486543 hasRelatedWork W4313356370 @default.
- W45486543 hasVolume "25" @default.
- W45486543 isParatext "false" @default.
- W45486543 isRetracted "false" @default.
- W45486543 magId "45486543" @default.
- W45486543 workType "article" @default.