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- W45487675 abstract "Avoiding drug–drug interactions is an important aspect of today’s drug discovery and development process. The most significant of these interactions occur through changes in the enzyme level of CYP3A4 which is involved in the metabolism of many drugs. Increases in the expression of CYP3A4 mRNA and enzyme activity can occur through several mechanisms, the most predominant of which is the activation of transcription factors, such as the nuclear hormone receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR). Through an understanding of interactions between drugs (ligands) and the ligand binding pockets of these receptors, several laboratories have attenuated the binding interactions and significantly reduced the potential for CYP3A4 induction and ultimately drug–drug interactions." @default.
- W45487675 created "2016-06-24" @default.
- W45487675 creator A5079110291 @default.
- W45487675 date "2013-01-01" @default.
- W45487675 modified "2023-09-26" @default.
- W45487675 title "Avoiding PXR and CAR Activation and CYP3A4 Enzyme Induction" @default.
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- W45487675 doi "https://doi.org/10.1007/7355_2013_24" @default.
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