FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W45505135> ?p ?o ?g. }

• W45505135 endingPage "129" @default.
• W45505135 startingPage "70" @default.
• W45505135 abstract "In this investigation the cell cycle time and the life-span of cells in different tissues of the mouse eye were determined during postfetal development not with single but, instead, by means of repeated 3H-thymidine injections. The potential of this method applied for the first time in the mammalian eye, is thoroughly discussed. Essentially, four groups of 19-21 mice each, aged 1, 10, 20, and 60 days at the start of the experiment, received intraperitoneal injections of 3H-thymidine at a dose of 1 microCi/g body weight every 4 h for a maximum of 14 days, i.e. a total of up to 85 injections. Further animals were sacrificed after the 13th, 19th, 25th, 31st, 37th, 49th, 61st, 73rd, and 85th injections, i.e. 2, 3, 4, 5, 6, 8, 10, 12, and 14 days after the start of the experiment. When all the injections had been given, animals from each group were sacrificed on the 1st, 4th, 8th, 16th, and sometimes the 32rd, 48th, and 64th days, respectively, after the last injection. With this experimental paradigm it was possible: (1) to determine the cell cycle time and the life-span of the cells during postfetal development up to maturity without gaps; (2) to establish the end of the development by means of cell proliferation in various tissues of the mouse eye; herewith it was possible to determine the times at which the development by cell proliferation is replaced by development by cell differentiation, and (3) to clearly prove in which mature ocular tissues cell turnover still exists and in which it does not; this appears to be especially important, since in recent years the importance of cell proliferation process following injury and stimulation was also recognized in the eye, for example, in massive periretinal proliferation in connection with retinal detachment and retinal surgery, as well as in endothelial injuries following intraocular lens implantation; only when normal conditions are known can pathological proliferative processes be recognized as such and be distinguished from normal ones. The results are cumulatively represented in tabular form, from which details are to be extracted. As expected, cell cycle times are very short and seemingly homogeneous in tissues which develop within themselves, but become longer and inhomogeneous, except in the inner and outer granular layer of the retina, in which the cell proliferation comes to a particularly abrupt end. The shortest cell cycle time occurred in the cells of the vascular walls of the retina at the time of birth and was 24 h.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W45505135 created "2016-06-24" @default.
• W45505135 creator A5013250321 @default.
• W45505135 creator A5024600316 @default.
• W45505135 creator A5040953723 @default.
• W45505135 date "1985-01-01" @default.
• W45505135 modified "2023-09-27" @default.
• W45505135 title "Cell cycle time and life-span of cells in the mouse eye. Measurements during the postfetal period using repeated 3H-thymidine injections." @default.
• W45505135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4029465" @default.
• W45505135 hasPublicationYear "1985" @default.
• W45505135 type Work @default.
• W45505135 sameAs 45505135 @default.
• W45505135 citedByCount "6" @default.
• W45505135 countsByYear W455051352022 @default.
• W45505135 crossrefType "journal-article" @default.
• W45505135 hasAuthorship W45505135A5013250321 @default.
• W45505135 hasAuthorship W45505135A5024600316 @default.
• W45505135 hasAuthorship W45505135A5040953723 @default.
• W45505135 hasConcept C121332964 @default.
• W45505135 hasConcept C134018914 @default.
• W45505135 hasConcept C1491633281 @default.
• W45505135 hasConcept C16685009 @default.
• W45505135 hasConcept C24890656 @default.
• W45505135 hasConcept C2777108182 @default.
• W45505135 hasConcept C2780159080 @default.
• W45505135 hasConcept C2781291010 @default.
• W45505135 hasConcept C29537977 @default.
• W45505135 hasConcept C2988516024 @default.
• W45505135 hasConcept C552990157 @default.
• W45505135 hasConcept C55493867 @default.
• W45505135 hasConcept C62112901 @default.
• W45505135 hasConcept C71924100 @default.
• W45505135 hasConcept C74909509 @default.
• W45505135 hasConcept C86803240 @default.
• W45505135 hasConceptScore W45505135C121332964 @default.
• W45505135 hasConceptScore W45505135C134018914 @default.
• W45505135 hasConceptScore W45505135C1491633281 @default.
• W45505135 hasConceptScore W45505135C16685009 @default.
• W45505135 hasConceptScore W45505135C24890656 @default.
• W45505135 hasConceptScore W45505135C2777108182 @default.
• W45505135 hasConceptScore W45505135C2780159080 @default.
• W45505135 hasConceptScore W45505135C2781291010 @default.
• W45505135 hasConceptScore W45505135C29537977 @default.
• W45505135 hasConceptScore W45505135C2988516024 @default.
• W45505135 hasConceptScore W45505135C552990157 @default.
• W45505135 hasConceptScore W45505135C55493867 @default.
• W45505135 hasConceptScore W45505135C62112901 @default.
• W45505135 hasConceptScore W45505135C71924100 @default.
• W45505135 hasConceptScore W45505135C74909509 @default.
• W45505135 hasConceptScore W45505135C86803240 @default.
• W45505135 hasLocation W455051351 @default.
• W45505135 hasOpenAccess W45505135 @default.
• W45505135 hasPrimaryLocation W455051351 @default.
• W45505135 hasRelatedWork W1608658497 @default.
• W45505135 hasRelatedWork W2067421708 @default.
• W45505135 hasRelatedWork W2072481810 @default.
• W45505135 hasRelatedWork W2141711640 @default.
• W45505135 hasRelatedWork W2351474733 @default.
• W45505135 hasRelatedWork W2361888356 @default.
• W45505135 hasRelatedWork W2389348259 @default.
• W45505135 hasRelatedWork W2906524453 @default.
• W45505135 hasRelatedWork W2919076918 @default.
• W45505135 hasRelatedWork W315696163 @default.
• W45505135 hasVolume "12" @default.
• W45505135 isParatext "false" @default.
• W45505135 isRetracted "false" @default.
• W45505135 magId "45505135" @default.
• W45505135 workType "article" @default.