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• W45522009 abstract "Ciliopathies are a group of diseases associated with abnormal structure or function of primary cilia. Ciliopathies include polycystic kidney disease (PKD), a pathology associated with vascular hypertension. We previously showed that cilia length regulates cilia function, and cilia function is required for nitric oxide (NO) biosynthesis in endothelial cells. Because patients with PKD show abnormal sensory cilia function, the aim of our current study was to search for a targeted therapy focused on primary cilia, which we refer to as 'ciliotherapy'.In the present studies, our in vitro analyses refined fenoldopam as an equipotent and more specific dopaminergic agonist to regulate cilia length and function. Our in vivo studies indicated that fenoldopam increased cilia length and serum NO thereby reducing blood pressure in a PKD mouse model. Our crossover, multicenter, double-blind and placebo-controlled clinical study further indicated that cilia-targeting therapy showed an overall reduction in mean arterial pressure in PKD patients.Overall, our studies provide the first evidence of ciliotherapy as an innovative intervention in patients with abnormal primary cilia." @default.
• W45522009 created "2016-06-24" @default.
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• W45522009 date "2014-03-01" @default.
• W45522009 modified "2023-09-29" @default.
• W45522009 title "Ciliotherapy: a novel intervention in polycystic kidney disease." @default.
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• W45522009 doi "https://doi.org/10.3969/j.issn.1671-5411.2014.01.001" @default.
• W45522009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3981986" @default.
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