FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W45525069> ?p ?o ?g. }

• W45525069 abstract "OBJECTIVE: We sought to define whether diffusion tensor imaging (DTI)-based quantitative assessment of the degree of ischemic injury to the corticospinal tract (CST) correlates with motor impairment clinical scores at each phase of ischemic stroke and whether the early CST changes predict the final motor outcome after stroke. BACKGROUND: Motor impairment is the leading form of disability after ischemic stroke and has been related to ischemic lesion location and size, and age. Direct injury to CST likely is a major contributing factor of present and subsequent motor impairment. Diffusion tensor tractography analysis allows the definition of white matter tracts, mainly the CST. DESIGN/METHODS: We prospectively evaluated patients with ischemic stroke at the acute (2-7 days), subacute (30 days) and outcome (90 days) phases with DTI and upper extremity Fugl-Meyer assessment (UE-FM). The CST was reconstructed based on DTI images that were acquired in a 3T MRI unit. Virtual fiber numbers (FN) were calculated for the affected and contralateral unaffected CST at each time point. Spearman9s correlation coefficients were computed for the correlation between FN ratio (affected/unaffected CST) and the UE-FM at each time point. A multivariable regression model for outcome UE-FM score prediction was also developed. RESULTS: We studied 22 patients, 13 (59%) were men, age was 67(±12.5) years. Ischemic lesion location was: cortically-based hemispheric (n=16), subcortical (n=5), brainstem/cerebellum (n=1). The FN ratio significantly correlated with UE-FM scores at each time point (Acute: r=0.51, p=0.032; Subacute: r=0.56, p=0.0096; Outcome: r=0.62, p=0.0044). Baseline FN ratio significantly predicted outcome UE-FM score at outcome (p=0.008). CONCLUSIONS: The degree of CST involvement by ischemic stroke on DTT strongly correlates with the degree of motor impairment at each phase of ischemic stroke. The baseline FN predicts motor outcome. DTI-derived CST assessment could become a surrogate marker of motor impairment in the design of future restorative clinical trials. Supported by: 1) NIH-NINDS Grant R01 NS70922, 2) Mort and Brigitte Harris Stroke Fund. Disclosure: Dr. Maraka has nothing to disclose. Dr. Jiang has nothing to disclose. Dr. Jafari-Khouzani has nothing to disclose. Dr. Hamidian has nothing to disclose. Dr. Li has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Lu has nothing to disclose. Dr. Soltanian-Zadeh has nothing to disclose. Dr. Mitsias has nothing to disclose." @default.
• W45525069 created "2016-06-24" @default.
• W45525069 creator A5000323703 @default.
• W45525069 creator A5010113236 @default.
• W45525069 creator A5021641134 @default.
• W45525069 creator A5032161433 @default.
• W45525069 creator A5042581616 @default.
• W45525069 creator A5043844658 @default.
• W45525069 creator A5058761102 @default.
• W45525069 creator A5061100984 @default.
• W45525069 creator A5080046965 @default.
• W45525069 creator A5088454909 @default.
• W45525069 date "2013-02-12" @default.
• W45525069 modified "2023-09-26" @default.
• W45525069 title "Quantitative Assessment of Corticospinal Tract Injury on Diffusion Tensor Imaging Correlates with Motor Outcome after Ischemic Stroke (P03.163)" @default.
• W45525069 hasPublicationYear "2013" @default.
• W45525069 type Work @default.
• W45525069 sameAs 45525069 @default.
• W45525069 citedByCount "0" @default.
• W45525069 crossrefType "journal-article" @default.
• W45525069 hasAuthorship W45525069A5000323703 @default.
• W45525069 hasAuthorship W45525069A5010113236 @default.
• W45525069 hasAuthorship W45525069A5021641134 @default.
• W45525069 hasAuthorship W45525069A5032161433 @default.
• W45525069 hasAuthorship W45525069A5042581616 @default.
• W45525069 hasAuthorship W45525069A5043844658 @default.
• W45525069 hasAuthorship W45525069A5058761102 @default.
• W45525069 hasAuthorship W45525069A5061100984 @default.
• W45525069 hasAuthorship W45525069A5080046965 @default.
• W45525069 hasAuthorship W45525069A5088454909 @default.
• W45525069 hasConcept C105702510 @default.
• W45525069 hasConcept C126322002 @default.
• W45525069 hasConcept C126838900 @default.
• W45525069 hasConcept C127413603 @default.
• W45525069 hasConcept C142724271 @default.
• W45525069 hasConcept C143409427 @default.
• W45525069 hasConcept C149550507 @default.
• W45525069 hasConcept C164705383 @default.
• W45525069 hasConcept C2778583998 @default.
• W45525069 hasConcept C2779779279 @default.
• W45525069 hasConcept C2780645631 @default.
• W45525069 hasConcept C2781156865 @default.
• W45525069 hasConcept C2781192897 @default.
• W45525069 hasConcept C3020199598 @default.
• W45525069 hasConcept C541997718 @default.
• W45525069 hasConcept C551621295 @default.
• W45525069 hasConcept C71924100 @default.
• W45525069 hasConcept C78519656 @default.
• W45525069 hasConcept C84787856 @default.
• W45525069 hasConcept C99508421 @default.
• W45525069 hasConceptScore W45525069C105702510 @default.
• W45525069 hasConceptScore W45525069C126322002 @default.
• W45525069 hasConceptScore W45525069C126838900 @default.
• W45525069 hasConceptScore W45525069C127413603 @default.
• W45525069 hasConceptScore W45525069C142724271 @default.
• W45525069 hasConceptScore W45525069C143409427 @default.
• W45525069 hasConceptScore W45525069C149550507 @default.
• W45525069 hasConceptScore W45525069C164705383 @default.
• W45525069 hasConceptScore W45525069C2778583998 @default.
• W45525069 hasConceptScore W45525069C2779779279 @default.
• W45525069 hasConceptScore W45525069C2780645631 @default.
• W45525069 hasConceptScore W45525069C2781156865 @default.
• W45525069 hasConceptScore W45525069C2781192897 @default.
• W45525069 hasConceptScore W45525069C3020199598 @default.
• W45525069 hasConceptScore W45525069C541997718 @default.
• W45525069 hasConceptScore W45525069C551621295 @default.
• W45525069 hasConceptScore W45525069C71924100 @default.
• W45525069 hasConceptScore W45525069C78519656 @default.
• W45525069 hasConceptScore W45525069C84787856 @default.
• W45525069 hasConceptScore W45525069C99508421 @default.
• W45525069 hasLocation W455250691 @default.
• W45525069 hasOpenAccess W45525069 @default.
• W45525069 hasPrimaryLocation W455250691 @default.
• W45525069 hasRelatedWork W1549573233 @default.
• W45525069 hasRelatedWork W1716470617 @default.
• W45525069 hasRelatedWork W1838401700 @default.
• W45525069 hasRelatedWork W1963280683 @default.
• W45525069 hasRelatedWork W1976875825 @default.
• W45525069 hasRelatedWork W2069247533 @default.
• W45525069 hasRelatedWork W2231364502 @default.
• W45525069 hasRelatedWork W2298593819 @default.
• W45525069 hasRelatedWork W2350702471 @default.
• W45525069 hasRelatedWork W2361697606 @default.
• W45525069 hasRelatedWork W2370741684 @default.
• W45525069 hasRelatedWork W2373259545 @default.
• W45525069 hasRelatedWork W2375614573 @default.
• W45525069 hasRelatedWork W2379435979 @default.
• W45525069 hasRelatedWork W2757750392 @default.
• W45525069 hasRelatedWork W2791711565 @default.
• W45525069 hasRelatedWork W2968532131 @default.
• W45525069 hasRelatedWork W3167364476 @default.
• W45525069 hasRelatedWork W3205185752 @default.
• W45525069 hasRelatedWork W2150565181 @default.
• W45525069 hasVolume "80" @default.
• W45525069 isParatext "false" @default.
• W45525069 isRetracted "false" @default.
• W45525069 magId "45525069" @default.
• W45525069 workType "article" @default.