Matches in SemOpenAlex for { <https://semopenalex.org/work/W45536124> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W45536124 abstract "The current thesis is aimed to increase our understanding of the generation and differentiation of telencephalic neurons, with emphasis on the role of glial cells in these processes. Using in vitro methods we have studied the role of glial cells in neurogenesis, inheritance of genetic regional specification, and influence on differentiation of neurons. We demonstrate that expanded cell cultures exhibiting glial characteristics produce neurons when EGF and serum is removed from the culture medium. At least some of the neurons are generated by GFAP expressing progenitor cells. Proliferating (i.e. undifferentiated) progenitor cells expanded under different culture conditions exhibit distinct expression profiles of region specific genes. LGE precursor cells expanded as attached cultures are most similar to LGE subventricular zone cells, while progenitor cells within LGE neurospheres resemble LGE ventricular zone cells. Despite the differences in gene expression in the proliferating cell cultures, the neurons generated by expanded LGE attached or neurosphere cultures, in vitro, are comparable. Furthermore, expanded glial cultures from the LGE produce retinoic acid after 4 passages (at P4), but not at P9. MGE glial cultures do not produce retinoic acid. In co-culture with glial cultures maturation of primary LGE neurons is influenced. LGE neurons co-cultured with LGE glia grow long neurites, while they develop short processes on MGE glia. Furthermore, twice as many DARPP-32 positive neurons are produced in co-culture with retinoic acid producing P4 LGE glia, as compared to on non-retinoic acid producing P9 LGE glia or P5 MGE glia." @default.
- W45536124 created "2016-06-24" @default.
- W45536124 creator A5060347852 @default.
- W45536124 date "2003-01-01" @default.
- W45536124 modified "2023-09-28" @default.
- W45536124 title "EMBRYONIC GLIA AND FOREBRAIN NEUROGENESIS; in vitro generation and differentiation of telencephalic neurons" @default.
- W45536124 hasPublicationYear "2003" @default.
- W45536124 type Work @default.
- W45536124 sameAs 45536124 @default.
- W45536124 citedByCount "0" @default.
- W45536124 crossrefType "dissertation" @default.
- W45536124 hasAuthorship W45536124A5060347852 @default.
- W45536124 hasConcept C104317684 @default.
- W45536124 hasConcept C113246987 @default.
- W45536124 hasConcept C145103041 @default.
- W45536124 hasConcept C148738053 @default.
- W45536124 hasConcept C162746124 @default.
- W45536124 hasConcept C169760540 @default.
- W45536124 hasConcept C201750760 @default.
- W45536124 hasConcept C202751555 @default.
- W45536124 hasConcept C20875687 @default.
- W45536124 hasConcept C26805974 @default.
- W45536124 hasConcept C2780884517 @default.
- W45536124 hasConcept C2781121885 @default.
- W45536124 hasConcept C28328180 @default.
- W45536124 hasConcept C4746552 @default.
- W45536124 hasConcept C529278444 @default.
- W45536124 hasConcept C54355233 @default.
- W45536124 hasConcept C81885089 @default.
- W45536124 hasConcept C86803240 @default.
- W45536124 hasConcept C95444343 @default.
- W45536124 hasConceptScore W45536124C104317684 @default.
- W45536124 hasConceptScore W45536124C113246987 @default.
- W45536124 hasConceptScore W45536124C145103041 @default.
- W45536124 hasConceptScore W45536124C148738053 @default.
- W45536124 hasConceptScore W45536124C162746124 @default.
- W45536124 hasConceptScore W45536124C169760540 @default.
- W45536124 hasConceptScore W45536124C201750760 @default.
- W45536124 hasConceptScore W45536124C202751555 @default.
- W45536124 hasConceptScore W45536124C20875687 @default.
- W45536124 hasConceptScore W45536124C26805974 @default.
- W45536124 hasConceptScore W45536124C2780884517 @default.
- W45536124 hasConceptScore W45536124C2781121885 @default.
- W45536124 hasConceptScore W45536124C28328180 @default.
- W45536124 hasConceptScore W45536124C4746552 @default.
- W45536124 hasConceptScore W45536124C529278444 @default.
- W45536124 hasConceptScore W45536124C54355233 @default.
- W45536124 hasConceptScore W45536124C81885089 @default.
- W45536124 hasConceptScore W45536124C86803240 @default.
- W45536124 hasConceptScore W45536124C95444343 @default.
- W45536124 hasLocation W455361241 @default.
- W45536124 hasOpenAccess W45536124 @default.
- W45536124 hasPrimaryLocation W455361241 @default.
- W45536124 hasRelatedWork W1602179738 @default.
- W45536124 hasRelatedWork W1976973435 @default.
- W45536124 hasRelatedWork W1987781672 @default.
- W45536124 hasRelatedWork W2000632805 @default.
- W45536124 hasRelatedWork W2002709921 @default.
- W45536124 hasRelatedWork W2019769907 @default.
- W45536124 hasRelatedWork W2029050180 @default.
- W45536124 hasRelatedWork W2038953101 @default.
- W45536124 hasRelatedWork W2041433311 @default.
- W45536124 hasRelatedWork W2057486544 @default.
- W45536124 hasRelatedWork W2065264755 @default.
- W45536124 hasRelatedWork W2081768529 @default.
- W45536124 hasRelatedWork W2086490478 @default.
- W45536124 hasRelatedWork W2087963198 @default.
- W45536124 hasRelatedWork W2090042357 @default.
- W45536124 hasRelatedWork W2094024307 @default.
- W45536124 hasRelatedWork W2135668873 @default.
- W45536124 hasRelatedWork W2160625834 @default.
- W45536124 hasRelatedWork W797144263 @default.
- W45536124 hasRelatedWork W173443861 @default.
- W45536124 isParatext "false" @default.
- W45536124 isRetracted "false" @default.
- W45536124 magId "45536124" @default.
- W45536124 workType "dissertation" @default.