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- W45584074 abstract "The autoimmune disease lupus erythematosus shows many different clinical manifestations, reaching from primarily cutaneous lesions – cutaneous lupus erythematosus (CLE) – to severe systemic organ manifestations. Various environmental factors influence the clinical expression of the disease and a striking relationship has emerged between sunlight exposure and the various subtypes of CLE. Although the mechanism by which ultraviolet (UV) irradiation activates the autoimmune response is not fully understood, recent studies addressing the molecular mechanisms underlying UV-induced apoptosis contribute to a better understanding of the disease pathogenesis. Further elucidation of the relevant factors will lead to the development of effective strategies to prevent abnormal humoral and cellular reactivity in patients with CLE." @default.
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- W45584074 date "2008-01-01" @default.
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- W45584074 title "Lupus Erythematosus: Pathogenesis of Cutaneous Manifestations" @default.
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- W45584074 doi "https://doi.org/10.1016/b978-012373960-5.00417-2" @default.
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