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- W45603240 abstract "Liver flukes of the family Opisthorchiidae consist of three medically important species, namely Clonorchis sinensis, Opisthorchis felineus and Opisthorchis viverrini. These liver flukes infect at least 40 million people and estimated 700 million people worldwide are at risk of being infected. Of the three currently recognized species, only O. viverrini is classified as a type 1 carcinogen because of its role as an initiator of chronic inflammation leading to subsequent development of cholangiocarcinoma (CCA). At present, there is no early diagnosis of CCA, the patients usually come to the doctor with advanced stages and die within 3 - 6 months. Importantly, this species of liver fluke is most commonly found in Southeast Asia. Especially, an estimated 9 million people are infected in Thailand, that the cost of treatment of opisthorchiasis is approximately $120 million dollars annually for lost wages and medical care. High accuracy and sensitivity diagnostic methods are therefore required for efficient control, prevention and treatment of opisthorchiasis. To date, there are three main methods for opisthorchiasis diagnosis, i.e. parasitological method, which is standard method for microscopy-based identification of diagnosis stage such as egg in fecal sample. However, its sensitivity and specificity are low due to limitations of skill and expert of distinguishing egg morphology. Thus, immunological methods and molecular methods to identify the opisthorchiasis were developed to improve sensitivity and specificity of diagnostic tools. This review article aims to compile all opisthorchiasis diagnostic methods in order to obtain the suitable guideline for the effective diagnosis of opisthorchiasis." @default.
- W45603240 created "2016-06-24" @default.
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- W45603240 date "2009-12-24" @default.
- W45603240 modified "2023-09-23" @default.
- W45603240 title "Diagnostic tools for human opisthorchaisis" @default.
- W45603240 hasPublicationYear "2009" @default.
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