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- W45604851 abstract "Supercritical fluid chromatography (SFC) is a separation technique closely related to high-performance liquid chromatography (HPLC) and ultra-high-performance liquid chromatography (UPLC or UHPLC), except most of the mobile phase is replaced by dense carbon dioxide (CO 2 ). The physical characteristics of CO 2 allow much higher speed separation, compared to HPLC or UPLC, on the same-sized particles, while at the same time causing much lower pressure drops across the column. The solvation characteristics of mobile phases consisting of CO 2 mixed with one or more organic modifiers makes it ideal for the separation of small drug-like molecules. SFC is increasingly used at both the analytical and semi-preparative scale for chiral separations, due to its high speed, low cost, easy dry-down and “green” aspects. For semi-preparative scale chromatography, the higher inherent flow required in SFC translates directly into much higher throughput, compared to HPLC. SFC has the major advantage that most of the mobile phase flash vaporizes when the pressure is dropped to near atmospheric, leaving much smaller organic fractions to dry down." @default.
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- W45604851 date "2012-01-01" @default.
- W45604851 modified "2023-10-10" @default.
- W45604851 title "8.18 Chromatographic Separations and Analysis: Supercritical Fluid Chromatography for Chiral Analysis and Semi-Preparative Purification" @default.
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- W45604851 doi "https://doi.org/10.1016/b978-0-08-095167-6.00836-3" @default.
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