Matches in SemOpenAlex for { <https://semopenalex.org/work/W45621331> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W45621331 endingPage "7" @default.
- W45621331 startingPage "600" @default.
- W45621331 abstract "Indomethacin, an NSAID capable of inhibiting the effect of both cyclooxygenase and lipooxygenase, has been reported to repress the growth of breast cancer, skin cancer and head & neck cancer, etc. Inhibition in the some cell lines of oral squamous cell carcinoma (OSCC) has also been reported. The purpose of this study was primarily to explore the cellular response of human OSCC lines after indomethacin or retinoic acid (RA) treatment and its correlation to apoptosis phenomenon.Five human OSCC cell lines--KB, SCC15, SCC25, OEC-M1 and OC2--were used for this in vitro study. By direct cell number counting, the cellular response was observed under incremental indomethacin concentrations of 50 microM, 100 microM, 200 microM and 400 microM, in order to select the most appropriate concentration for further study. Then 200 microM indomethacin and all-trans RA at 1 microM were used in the 2nd experiment to explore the intensity of their inhibitory effects individually and potential synergistic inhibition when exerted together. While in the 3rd part, TdT-mediated-dUTP nick-end labeling (TUNEL) method was used for in situ apoptosis assay to see if the apoptosis rate varied with these two agents.All 5 cell lines constantly showed growth suppression with positive dosage effect of indomethacin. Synergistic inhibition by combined treatment of indomethacin and RA was seen in RA responsive lines of SCC15 and SCC25, whereas other RA-resistant clones showed no synergism of this combined treatment. The in situ detection of apoptosis by TUNEL assay revealed a significantly higher ratio of apoptotic cells in the indomethacin/RA treated SCC15 and SCC25 than in controls.The study provides the value of further exploration on the mechanism of how indomethacin inhibiting cancer cell growth and how RA-sensitive OSCC cell lines are synergistically suppressed by conjoint treatment of RA and indomethacin. This study also highlights the value to see how the apoptotic pathway responds differently to the indomethacin/RA treatment." @default.
- W45621331 created "2016-06-24" @default.
- W45621331 creator A5002454387 @default.
- W45621331 creator A5005679106 @default.
- W45621331 creator A5012514560 @default.
- W45621331 creator A5024060303 @default.
- W45621331 creator A5059842261 @default.
- W45621331 date "2002-12-01" @default.
- W45621331 modified "2023-09-23" @default.
- W45621331 title "In vitro growth inhibition by indomethacin on human oral squamous cell carcinoma lines synergistically suppressed by all-trans retinoic acid correlating to apoptosis." @default.
- W45621331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12636206" @default.
- W45621331 hasPublicationYear "2002" @default.
- W45621331 type Work @default.
- W45621331 sameAs 45621331 @default.
- W45621331 citedByCount "0" @default.
- W45621331 crossrefType "journal-article" @default.
- W45621331 hasAuthorship W45621331A5002454387 @default.
- W45621331 hasAuthorship W45621331A5005679106 @default.
- W45621331 hasAuthorship W45621331A5012514560 @default.
- W45621331 hasAuthorship W45621331A5024060303 @default.
- W45621331 hasAuthorship W45621331A5059842261 @default.
- W45621331 hasConcept C121608353 @default.
- W45621331 hasConcept C126322002 @default.
- W45621331 hasConcept C153911025 @default.
- W45621331 hasConcept C185592680 @default.
- W45621331 hasConcept C190283241 @default.
- W45621331 hasConcept C196795494 @default.
- W45621331 hasConcept C202751555 @default.
- W45621331 hasConcept C2777546739 @default.
- W45621331 hasConcept C2779707156 @default.
- W45621331 hasConcept C2781121885 @default.
- W45621331 hasConcept C2994491419 @default.
- W45621331 hasConcept C502942594 @default.
- W45621331 hasConcept C54355233 @default.
- W45621331 hasConcept C55493867 @default.
- W45621331 hasConcept C62112901 @default.
- W45621331 hasConcept C71924100 @default.
- W45621331 hasConcept C81885089 @default.
- W45621331 hasConcept C86803240 @default.
- W45621331 hasConcept C96232424 @default.
- W45621331 hasConcept C98274493 @default.
- W45621331 hasConceptScore W45621331C121608353 @default.
- W45621331 hasConceptScore W45621331C126322002 @default.
- W45621331 hasConceptScore W45621331C153911025 @default.
- W45621331 hasConceptScore W45621331C185592680 @default.
- W45621331 hasConceptScore W45621331C190283241 @default.
- W45621331 hasConceptScore W45621331C196795494 @default.
- W45621331 hasConceptScore W45621331C202751555 @default.
- W45621331 hasConceptScore W45621331C2777546739 @default.
- W45621331 hasConceptScore W45621331C2779707156 @default.
- W45621331 hasConceptScore W45621331C2781121885 @default.
- W45621331 hasConceptScore W45621331C2994491419 @default.
- W45621331 hasConceptScore W45621331C502942594 @default.
- W45621331 hasConceptScore W45621331C54355233 @default.
- W45621331 hasConceptScore W45621331C55493867 @default.
- W45621331 hasConceptScore W45621331C62112901 @default.
- W45621331 hasConceptScore W45621331C71924100 @default.
- W45621331 hasConceptScore W45621331C81885089 @default.
- W45621331 hasConceptScore W45621331C86803240 @default.
- W45621331 hasConceptScore W45621331C96232424 @default.
- W45621331 hasConceptScore W45621331C98274493 @default.
- W45621331 hasIssue "12" @default.
- W45621331 hasLocation W456213311 @default.
- W45621331 hasOpenAccess W45621331 @default.
- W45621331 hasPrimaryLocation W456213311 @default.
- W45621331 hasRelatedWork W2107855445 @default.
- W45621331 hasRelatedWork W2348725144 @default.
- W45621331 hasRelatedWork W2369925227 @default.
- W45621331 hasRelatedWork W2371373779 @default.
- W45621331 hasRelatedWork W2379654838 @default.
- W45621331 hasRelatedWork W2385874192 @default.
- W45621331 hasRelatedWork W2387313479 @default.
- W45621331 hasRelatedWork W2389705313 @default.
- W45621331 hasRelatedWork W2621385873 @default.
- W45621331 hasRelatedWork W45621331 @default.
- W45621331 hasVolume "65" @default.
- W45621331 isParatext "false" @default.
- W45621331 isRetracted "false" @default.
- W45621331 magId "45621331" @default.
- W45621331 workType "article" @default.