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- W45642253 abstract "The successes of EGFR targeted drugs and antiangiogenic agents in non-small cell lung cancer (NSCLC) have speed up the development of molecular agents targeting other pathways. Promising new targets are reviewed on this chapter with a special focus on (1) mTOR/PI3K and IGF-1R that might modulate the activity of cytotoxic drugs or EGFR targeted agents, (2) the RAS/Erk pathway that has an appealing new interest giving the recent advances on K-RAS predictive and prognostic value, (3) Met, recently highlighted as a candidate for EGFR inhibitor resistance, (4) protein kinase C or integrins, and their role in angiogenesis, (5) Bcl-2 and death receptors in the apoptotic field. We discuss the challenges that we are facing to implement these new drugs among the approved drugs and validated strategies." @default.
- W45642253 created "2016-06-24" @default.
- W45642253 creator A5021624793 @default.
- W45642253 creator A5023794502 @default.
- W45642253 date "2010-01-01" @default.
- W45642253 modified "2023-10-16" @default.
- W45642253 title "Other Molecular Targeted Agents in Non-small Cell Lung Cancer" @default.
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