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- W45648754 abstract "This chapter provides an overview about fosfomycin and derivatives. Fosfomycin belongs to the class of phosphonic antibiotics possessing a broad spectrum and exhibiting bactericidal activity against bacteria that fall within that spectrum. Two studies are reported in the literature; in one a broth medium was used to determine the MICs, while in the other the MICs in Mueller-Hinton agar were investigated. The in vitro activity of fosfomycin trometamol was better than that of pipemidic acid against Staphylococcus aureus and Enterococcus faecalis and better than that of amoxicillin against Escherichia coli and Klebsiella pneumoniae. Fosfomycin inhibits bacterial cell wall biosynthesis by acting on the initial stage in the synthesis of peptidoglycan precursors. N-Acetylglucosamine-3-O-enolpyruvyl transferase is essential for any bacterium possessing muramic acid in its cell wall structure, which accounts for the broad spectrum of antibacterial activity of fosfomycin since numerous gram-positive or -negative species possess muramic acid that constitutes cell wall peptidoglycan. For fosmidomycin, the principal intracellular target has not been identified. It would appear that fosfomycin and fosmidomycin have different targets in E. coli and/or that, in the absence of the hexose phosphate transport route, these two products are transported into the bacterial cell by different mechanisms. The results of studies of combinations of fosfomycin with other antibiotics, particularly β-lactams, are described in this chapter. Due to its good diffusion into bone, fosfomycin has been recommended in the treatment of staphylococcal bone and joint infections or those due to Pseudomonas." @default.
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- W45648754 date "2014-04-30" @default.
- W45648754 modified "2023-10-18" @default.
- W45648754 title "Fosfomycin and Derivatives" @default.
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- W45648754 doi "https://doi.org/10.1128/9781555815929.ch37" @default.
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