Matches in SemOpenAlex for { <https://semopenalex.org/work/W45671463> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W45671463 endingPage "138.28" @default.
- W45671463 startingPage "138.28" @default.
- W45671463 abstract "Abstract Development of T cells from T cell precursors occurs in the thymus through interactions of T lineage cells with thymic stromal populations. These stromal populations are distributed in an ordered fashion that defines thymic architecture and provides the environment for thymic differentiation. The successful generation of a mature and self-tolerant CD4 T cell repertoire requires that developing T cells pass at least two checkpoints; positive and negative selection. Positive selection has been reported to be mediated by cortical epithelial cells, allowing T lineage cells that have rearranged a T cell receptor capable of recognizing self peptide-MHCII complexes at appropriately affinity, to survive and commit to the CD4 lineage. Positively selected cells can then move into the medulla where they must pass negative selection, which acts to remove highly self reactive cells. MHCII is expressed in the medulla on both medullary epithelial cells and dendritic cells and plays a critical role in negative selection. To further examine the cell populations in which MHCII expression is important in CD4 T cell development in unmanipulated mice, we are characterizing the effect of selective inactivation of MHCII, using a panel of mice expressing cre recombinase specifically in epithelial cells or in dendritic cells in combination with an MHCII floxed allele." @default.
- W45671463 created "2016-06-24" @default.
- W45671463 creator A5004192129 @default.
- W45671463 creator A5004257275 @default.
- W45671463 creator A5007930674 @default.
- W45671463 creator A5068577830 @default.
- W45671463 creator A5072102205 @default.
- W45671463 creator A5089977992 @default.
- W45671463 date "2009-04-01" @default.
- W45671463 modified "2023-10-02" @default.
- W45671463 title "Importance of MHCII expression on thymic epithelium versus dendritic cells for the positive and negative selection of CD4 T Cells (138.28)" @default.
- W45671463 doi "https://doi.org/10.4049/jimmunol.182.supp.138.28" @default.
- W45671463 hasPublicationYear "2009" @default.
- W45671463 type Work @default.
- W45671463 sameAs 45671463 @default.
- W45671463 citedByCount "1" @default.
- W45671463 countsByYear W456714632015 @default.
- W45671463 crossrefType "journal-article" @default.
- W45671463 hasAuthorship W45671463A5004192129 @default.
- W45671463 hasAuthorship W45671463A5004257275 @default.
- W45671463 hasAuthorship W45671463A5007930674 @default.
- W45671463 hasAuthorship W45671463A5068577830 @default.
- W45671463 hasAuthorship W45671463A5072102205 @default.
- W45671463 hasAuthorship W45671463A5089977992 @default.
- W45671463 hasConcept C104317684 @default.
- W45671463 hasConcept C141231307 @default.
- W45671463 hasConcept C16930146 @default.
- W45671463 hasConcept C203014093 @default.
- W45671463 hasConcept C2776090121 @default.
- W45671463 hasConcept C502942594 @default.
- W45671463 hasConcept C54355233 @default.
- W45671463 hasConcept C7386963 @default.
- W45671463 hasConcept C86803240 @default.
- W45671463 hasConcept C8891405 @default.
- W45671463 hasConcept C95444343 @default.
- W45671463 hasConceptScore W45671463C104317684 @default.
- W45671463 hasConceptScore W45671463C141231307 @default.
- W45671463 hasConceptScore W45671463C16930146 @default.
- W45671463 hasConceptScore W45671463C203014093 @default.
- W45671463 hasConceptScore W45671463C2776090121 @default.
- W45671463 hasConceptScore W45671463C502942594 @default.
- W45671463 hasConceptScore W45671463C54355233 @default.
- W45671463 hasConceptScore W45671463C7386963 @default.
- W45671463 hasConceptScore W45671463C86803240 @default.
- W45671463 hasConceptScore W45671463C8891405 @default.
- W45671463 hasConceptScore W45671463C95444343 @default.
- W45671463 hasIssue "1_Supplement" @default.
- W45671463 hasLocation W456714631 @default.
- W45671463 hasOpenAccess W45671463 @default.
- W45671463 hasPrimaryLocation W456714631 @default.
- W45671463 hasRelatedWork W155326310 @default.
- W45671463 hasRelatedWork W1994052653 @default.
- W45671463 hasRelatedWork W2110047633 @default.
- W45671463 hasRelatedWork W2130547308 @default.
- W45671463 hasRelatedWork W2414570438 @default.
- W45671463 hasRelatedWork W2442054100 @default.
- W45671463 hasRelatedWork W2463302271 @default.
- W45671463 hasRelatedWork W2747317233 @default.
- W45671463 hasRelatedWork W2889023565 @default.
- W45671463 hasRelatedWork W3088420852 @default.
- W45671463 hasVolume "182" @default.
- W45671463 isParatext "false" @default.
- W45671463 isRetracted "false" @default.
- W45671463 magId "45671463" @default.
- W45671463 workType "article" @default.