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- W45672086 abstract "Background We previously reported that coronary distensibility can be measured non-invasively using 3T MRI and that distensibility is reduced in coronary artery disease (CAD) patients compared with healthy subjects. Because atherosclerotic vascular disease is an inflammatory process, we sought to test the hypothesis that coronary distensibility measured with MRI is associated with systemic inflammation, measured by serum high sensitivity C reactive protein, hsCRP, a marker of increased inflammation, and adiponectin, a fat hormone associated with decreased inflammation, in healthy subjects and in CAD patients. Methods 25 subjects (8 healthy adults, age=38.6±6.5years, mean±standard error) and 17 patients with catheterization-documented CAD (age=59.4±3.4) were studied using a commercial whole-body MR imaging system (Achieva 3.0T;Philips,Best,Netherlands). Spiral cine MRI was performed for area measurements of a proximal coronary artery. MRI parameters were:echo time (TE)=1.5ms,radiofrequency(RF) excitation angle=20°;spectral spatial excitation,acq. window=10ms,repetition time(TR)=14ms,21 spiral interleaves,spatial resolution(acquired/recon" @default.
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- W45672086 date "2015-02-03" @default.
- W45672086 modified "2023-09-26" @default.
- W45672086 title "Decreased coronary artery distensibility measured using 3T MRI is related to systemic inflammation in patients with coronary artery disease" @default.
- W45672086 doi "https://doi.org/10.1186/1532-429x-17-s1-p400" @default.
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