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- W45704997 abstract "Magnetic Nanoparticle Hyperthermia (MNH) is a promising treatment for cancer offering the possibility of a generic low morbidity therapy. Currently available Fe oxide nanoparticles, however, are unable to produce enough heat per gram to enable MNH to work without using it in combination with other treatments and also restrict it to certain types of cancer. The search is on for magnetic nanoparticles that have a much higher Specific Absorption Rate (SAR), which describes the power converted into heat per unit mass (W/g). This usually means having a pure Fe core within the nanoparticle, which also entails producing the nanoparticles as a core-shell structure so that the outer part is biocompatible and protects the metallic core. Gas-phase synthesis offers the possibility of producing core-shell nanoparticles in which there is independent control of the core size and shell thickness and flexible choice of materials in either. The problem of getting the gas-phase nanoparticles into a liquid suspension has been solved by co-depositing the gas-phase nanoparticles with a narrow size distribution and water vapour in Ultra-High Vacuum (UHV) conditions[1]. The talk will present the method and the SAR performance of various core-shell nanoparticles produced this way. Due to the high magnetic moment of the nanoparticles synthesised by the new method they also have a high performance as MRI contrast enhancers. The new method even allows some control of the shape of the particles and the effect of this on MRI relaxivity will be presented. [1] C. Binns, P. Prieto, S. Baker, P. Howes, R. Dondi, G. Burley, L. Lari, R. Kroger, A. Pratt, S. Aktas and J. K. Mellon, Preparation of Hydrosol Suspensions of Elemental and Core-Shell Nanoparticles by Co-Deposition with Water Vapour from the Gas-Phase in Ultra-High Vacuum Conditions J. Nanoparticle Res. 14 (2012) 1136." @default.
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- W45704997 date "2013-07-31" @default.
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- W45704997 title "Gas-phase Synthesis of High Performance Ferrofluids for Medical Applications" @default.
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