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- W45709818 abstract "Publisher Summary This chapter describes the cytotoxicity of bone marrow macrophages for normal and malignant targets. Bone marrow cells cultured in liquid medium in the presence of colony stimulating factor proliferate and differentiate along the granulocyte and macrophage pathways. The cells can be cultured in large quantities from one mouse and harvested for experiments at any stage of maturation and activation. They are never intentionally pre-activated. These bone marrow-derived macrophages can then be activated to become cytotoxic by incubation with the lymphokine macrophage cytotoxicity factor. Both nonadherent precursor cells of early cultures as well as mature adherent macrophages of late cultures can be rendered cytotoxic. Thus, relatively immature macrophage precursors, such as promonocytes, can become cytotoxic even though the typical macrophage phenotype has not yet developed. The activated cells kill all tumor targets tested, but some cell types are more susceptible than others. The killing of target cells by activated macrophages is not restricted to neoplastic cells. Non-neoplastic cells are also susceptible to lysis, especially when they are mitotically stimulated." @default.
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- W45709818 date "1979-01-01" @default.
- W45709818 modified "2023-09-25" @default.
- W45709818 title "CYTOTOXICITY OF BONE MARROW MACROPHAGES FOR NORMAL AND MALIGNANT TARGETS" @default.
- W45709818 doi "https://doi.org/10.1016/b978-0-12-584650-9.50031-6" @default.
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