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- W45790100 abstract "Neuropeptide Y (NPY) has anxiolytic and orexigenic behavioral effects, and is involved in the regulation of alcohol drinking. Intracerebroventricular (ICV) administration of NPY suppresses alcohol intake in alcohol-preferring (P) rats, selectively bred for high voluntary oral alcohol intake. Previous findings indicate that endogenous NPY activity may be altered by chronic exposure to alcohol and alcohol withdrawal. The present experiments examine whether the behavioral effects of exogenously administered NPY are also altered by different histories of alcohol exposure. Female P rats had continuous access to 15% (v/v) alcohol and water for 6 weeks. This was followed by two or three 4-week alcohol access cycles, each consisting of 2 weeks with forced alcohol abstinence and 2 weeks with alcohol available. Following ICV cannulae implantation during the final period of alcohol abstinence, separate groups were infused with NPY (2.5, 5.0, 10.0 μg) or aCSF. Alcohol intake, food intake, and anxiety (light-enhanced acoustic startle response) were measured. Continuous access controls were treated similarly except that access to alcohol was not interrupted by periods of forced abstinence. NPY dose-dependently suppressed alcohol intake, increased food intake, and reduced anxiety. However, these effects were greater and/or longer in groups that underwent alcohol abstinence periods relative to continuous access controls. These results suggest that chronic drinking with periods of forced alcohol abstinence may produce a global dysregulation of NPY systems that enhances sensitivity to the behavioral effects of NPY. Supported by NIH grants AA12857, AA07611, and AA10722." @default.
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- W45790100 date "2006-03-01" @default.
- W45790100 modified "2023-10-18" @default.
- W45790100 title "Neuropeptide Y behavioral effects in alcohol‐preferring rats" @default.
- W45790100 doi "https://doi.org/10.1096/fasebj.20.4.a416" @default.
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