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- W45806021 abstract "We describe optical and microscopy methods based on Förster resonance energy transfer, fluorescence recovery after photobleaching, and imaging cross-correlation spectroscopy that permit to determine kinetic and dynamic properties of key reactions involved G protein-coupled receptor (GPCR) signaling from the initial ligand binding step to the generation of the second messenger, cAMP. Well suited to determine rate-limiting reactions taking place along a GPCR signaling cascade in live cells, these techniques have also uncovered new concepts in GPCR signaling as well as many interesting mechanistic subtleties by which GPCRs transmit neurotransmitter and hormone signals into cells." @default.
- W45806021 created "2016-06-24" @default.
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- W45806021 date "2013-01-01" @default.
- W45806021 modified "2023-10-16" @default.
- W45806021 title "Kinetics and Dynamics in the G Protein-Coupled Receptor Signaling Cascade" @default.
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- W45806021 doi "https://doi.org/10.1016/b978-0-12-407865-9.00016-9" @default.
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