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- W45862131 abstract "Muscarinic receptors bind acetylcholine to transduce signals in the central nervous system, autonomic ganglia, smooth muscles, and parasympathetic organs. The five closely related receptor subtypes (M1–M5) are members of the class A (rhodopsin-like) superfamily of G-protein-coupled receptors. These receptors possess seven membrane-spanning domains and specific sites for glycosylation, phosphorylation, lipid modification, and interaction with heterotrimeric transducer G-proteins. M1, M3, and M5 receptors are efficiently coupled through Gq/11 proteins to phospholipase Cβ, producing the second messengers diacylglycerol and inositol triphosphate. M2 and M4 receptors inhibit adenylate cyclase through actions involving Gi. Our understanding of muscarinic systems has advanced by analysis of receptor gene knockouts." @default.
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- W45862131 date "2009-01-01" @default.
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- W45862131 title "Muscarinic Receptors: Autonomic Neurons" @default.
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