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- W45872738 endingPage "160" @default.
- W45872738 startingPage "93" @default.
- W45872738 abstract "Thyroid hormone synthesis occurs within the follicles of the thyroid gland. This chapter describes the following steps involved in thyroid hormone synthesis: (1) inorganic iodide is transported into the gland; (2) intrathyroidal iodide is oxidized to iodine under the influence of H2O2 and peroxidase; (3) iodine is bound in thyroglobulin to tyrosine, forming monoiodotyrosine and diiodotyrosine; (4) the iodotyrosines are enzymatically coupled to form thyroxine (T4) and triiodothyronine (T3); (5) the iodothyronines, T4 and T3, are stored in thyroglobulin until released into the circulation; and (6) the unused iodotyrosines are deiodinated and the iodide is recycled. The thyroid hormone secretion is regulated by the central nervous system. T3-induced changes in specific messenger RNAs lead to the synthesis of particular proteins that mediate the response to thyroid hormone. Thyroid hormone, by inducing protein synthesis, may produce cardiac hypertrophy. Thyroid hormone exerts a major influence on myocardial contractility. Many of the symptoms and signs of hyperthyroidism resemble those of sympathetic stimulation, suggesting that the enhanced hemodynamics of hyperthyroidism may be because of hypersensitivity of the autonomic nervous system." @default.
- W45872738 created "2016-06-24" @default.
- W45872738 creator A5074325574 @default.
- W45872738 date "1980-01-01" @default.
- W45872738 modified "2023-10-14" @default.
- W45872738 title "Thyroid Hormone Effects on the Heart" @default.
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