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- W45883397 abstract "Since the discovery that neurotrophins can stimulate neuronal survival and function and promote axonal growth, there has been speculation that therapeutic application of these proteins could prevent or slow cell death in neurodegenerative diseases such as Alzheimer’s disease and enhance regeneration in the peripheral and central nervous system after injury. Early clinical trials were unsuccessful, however. Over the ensuing years knowledge evolved, indicating that site-specific delivery of growth factors across the blood–brain barrier but limited to regions of degenerating neurons would be required to safely deliver and adequately test their potential to treat neurodegenerative disorders. Recent developments indicate that gene therapy may achieve at least some of the requirements for successful clinical testing of neurotrophin therapy." @default.
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- W45883397 date "2009-01-01" @default.
- W45883397 modified "2023-10-16" @default.
- W45883397 title "Neurotrophic Factor Therapy: NGF, BDNF and NT-3" @default.
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- W45883397 doi "https://doi.org/10.1016/b978-008045046-9.00030-9" @default.
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