FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4594923> ?p ?o ?g. }

• W4594923 endingPage "E667" @default.
• W4594923 startingPage "E660" @default.
• W4594923 abstract "Parathyroid hormone (PTH)-stimulated signal transduction through mechanisms alternate to adenosine 3',5'-cyclic monophosphate (cAMP) production were studied in UMR 106-01 cells, a cell line with an osteoblastic phenotype. PTH produced transient, dose-related increases in cytosolic calcium [( Ca2+]i), inositol trisphosphates, and diacylglycerol (DAG). Both inositol 1,4,5-trisphosphate (Ins-1,4,5P3) and inositol 1,3,4-trisphosphate (Ins-1,3,4P3) production were rapidly stimulated by PTH. Consistent with the production of Ins-1,3,4P3, rapid stimulation of late eluting inositol tetrakisphosphate was observed. The effects on the inositol phosphates were induced rapidly, consistent with roles as signals for changes in [Ca2+]i. In saponin-permeabilized UMR 106-01 cells, Ins-1,4,5P3 stimulated 45Ca release from a nonmitochondrial intracellular pool. Thus the hypothesis that PTH-stimulated Ins-1,4,5P3 production initiates Ca2+ release and contributes to transient elevations of [Ca2+]i is supported. Pretreatment of UMR 106-01 cells with pertussis toxin had no effect on PTH stimulation of inositol phosphates. Pertussis toxin reduced PTH-stimulated elevations of [Ca2+]i, but cAMP analogues had an even greater effect than pertussis toxin. These data suggest that stimulation of cAMP production during PTH stimulation may negatively affect production of rises in [Ca2+]i during PTH stimulation. The inactivation of the inhibitory G protein of adenylate cyclase by pertussis toxin could explain its action similar to cAMP analogues. Cyclic nucleotides diminish the effects of PTH on [Ca2+]i, probably interacting on a biochemical step subsequent to or independent of Ins-1,4,5P3 release." @default.
• W4594923 created "2016-06-24" @default.
• W4594923 creator A5014691317 @default.
• W4594923 creator A5050299388 @default.
• W4594923 creator A5053097964 @default.
• W4594923 creator A5058399747 @default.
• W4594923 creator A5084433382 @default.
• W4594923 date "1988-11-01" @default.
• W4594923 modified "2023-10-09" @default.
• W4594923 title "PTH elevates inositol polyphosphates and diacylglycerol in a rat osteoblast-like cell line" @default.
• W4594923 cites W1043498583 @default.
• W4594923 cites W1485546348 @default.
• W4594923 cites W1495653195 @default.
• W4594923 cites W1516463671 @default.
• W4594923 cites W1521095349 @default.
• W4594923 cites W1576923208 @default.
• W4594923 cites W1581434205 @default.
• W4594923 cites W1802980406 @default.
• W4594923 cites W1895492779 @default.
• W4594923 cites W1973237558 @default.
• W4594923 cites W1976781991 @default.
• W4594923 cites W1982749890 @default.
• W4594923 cites W1993551565 @default.
• W4594923 cites W1997278925 @default.
• W4594923 cites W2001692359 @default.
• W4594923 cites W2008245136 @default.
• W4594923 cites W2018049259 @default.
• W4594923 cites W2025908951 @default.
• W4594923 cites W2028110085 @default.
• W4594923 cites W2039085452 @default.
• W4594923 cites W2055613747 @default.
• W4594923 cites W2061798706 @default.
• W4594923 cites W2068270309 @default.
• W4594923 cites W2068771093 @default.
• W4594923 cites W2082831896 @default.
• W4594923 cites W2086467257 @default.
• W4594923 cites W2141260882 @default.
• W4594923 cites W2214267384 @default.
• W4594923 cites W2293695516 @default.
• W4594923 cites W2336004361 @default.
• W4594923 doi "https://doi.org/10.1152/ajpendo.1988.255.5.e660" @default.
• W4594923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3263806" @default.
• W4594923 hasPublicationYear "1988" @default.
• W4594923 type Work @default.
• W4594923 sameAs 4594923 @default.
• W4594923 citedByCount "41" @default.
• W4594923 countsByYear W45949232013 @default.
• W4594923 crossrefType "journal-article" @default.
• W4594923 hasAuthorship W4594923A5014691317 @default.
• W4594923 hasAuthorship W4594923A5050299388 @default.
• W4594923 hasAuthorship W4594923A5053097964 @default.
• W4594923 hasAuthorship W4594923A5058399747 @default.
• W4594923 hasAuthorship W4594923A5084433382 @default.
• W4594923 hasConcept C126322002 @default.
• W4594923 hasConcept C134018914 @default.
• W4594923 hasConcept C163235415 @default.
• W4594923 hasConcept C170493617 @default.
• W4594923 hasConcept C185592680 @default.
• W4594923 hasConcept C195794163 @default.
• W4594923 hasConcept C24998067 @default.
• W4594923 hasConcept C2777427919 @default.
• W4594923 hasConcept C2778597717 @default.
• W4594923 hasConcept C2778618036 @default.
• W4594923 hasConcept C2781208988 @default.
• W4594923 hasConcept C2781387506 @default.
• W4594923 hasConcept C36020004 @default.
• W4594923 hasConcept C49773422 @default.
• W4594923 hasConcept C519063684 @default.
• W4594923 hasConcept C55493867 @default.
• W4594923 hasConcept C62478195 @default.
• W4594923 hasConcept C71924100 @default.
• W4594923 hasConcept C79879829 @default.
• W4594923 hasConcept C80631254 @default.
• W4594923 hasConcept C86803240 @default.
• W4594923 hasConceptScore W4594923C126322002 @default.
• W4594923 hasConceptScore W4594923C134018914 @default.
• W4594923 hasConceptScore W4594923C163235415 @default.
• W4594923 hasConceptScore W4594923C170493617 @default.
• W4594923 hasConceptScore W4594923C185592680 @default.
• W4594923 hasConceptScore W4594923C195794163 @default.
• W4594923 hasConceptScore W4594923C24998067 @default.
• W4594923 hasConceptScore W4594923C2777427919 @default.
• W4594923 hasConceptScore W4594923C2778597717 @default.
• W4594923 hasConceptScore W4594923C2778618036 @default.
• W4594923 hasConceptScore W4594923C2781208988 @default.
• W4594923 hasConceptScore W4594923C2781387506 @default.
• W4594923 hasConceptScore W4594923C36020004 @default.
• W4594923 hasConceptScore W4594923C49773422 @default.
• W4594923 hasConceptScore W4594923C519063684 @default.
• W4594923 hasConceptScore W4594923C55493867 @default.
• W4594923 hasConceptScore W4594923C62478195 @default.
• W4594923 hasConceptScore W4594923C71924100 @default.
• W4594923 hasConceptScore W4594923C79879829 @default.
• W4594923 hasConceptScore W4594923C80631254 @default.
• W4594923 hasConceptScore W4594923C86803240 @default.
• W4594923 hasIssue "5" @default.
• W4594923 hasLocation W45949231 @default.
• W4594923 hasLocation W45949232 @default.

• next