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- W46001593 abstract "Immunoglobulin κ (IGK) locus rearrangements were analyzed in parallel on cDNA/genomic DNA in 188 κ- and 103 λ-chronic lymphocytic leukemia (CLL) cases. IGKV-KDE and IGKJ-C-intron-KDE rearrangements were also analyzed on genomic DNA. In κ-CLL, only 3 of 188 cases carried double in-frame IGKV-J transcripts: in such cases, the possibility that leukemic cells expressed more than one k chain cannot be excluded. Twenty-eight κ-CLL cases also carried nonexpressed (nontranscribed and/or out-of-frame) IGKV-J rearrangements. Taking IGKV-J, IGKV-KDE, and IGKJ-C-intron-KDE rearrangements together, 38% of κ-CLL cases carried biallelic IGK locus rearrangements. In λ-CLL, 69 IGKV-J rearrangements were detected in 64 of 103 cases (62%); 24 rearrangements (38.2%) were in-frame. Four cases carried in-frame IGKV-J transcripts but retained monotypic light-chain expression, suggesting posttranscriptional regulation of allelic exclusion. In all, taking IGKV-J, IGKV-KDE, and IGKJ-C-intron-KDE rearrangements together, 97% of λ-CLL cases had at least 1 rearranged IGK allele, in keeping with normal cells. IG repertoire comparisons in κ- versus λ-CLL revealed that CLL precursor cells tried many rearrangements on the same IGK allele before they became λ producers. Thirteen of 28 and 26 of 69 non-expressed sequences in, respectively, κ- or λ-CLL had < 100% homology to germline. This finding might be considered as evidence for secondary rearrangements occurring after the onset of somatic hypermutation, at least in some cases. The inactivation of potentially functional IGKV-J joints by secondary rearrangements indicates active receptor editing in CLL and provides further evidence for the role of antigen in CLL immunopathogenesis." @default.
- W46001593 created "2016-06-24" @default.
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- W46001593 date "2005-01-01" @default.
- W46001593 modified "2023-10-16" @default.
- W46001593 title "Analysis of Expressed and Non-Expressed IGK Locus Rearrangements in Chronic Lymphocytic Leukemia" @default.
- W46001593 cites W100854673 @default.
- W46001593 cites W1514910482 @default.
- W46001593 cites W1534264803 @default.
- W46001593 cites W1561187831 @default.
- W46001593 cites W1572006684 @default.
- W46001593 cites W1580036772 @default.
- W46001593 cites W1588794320 @default.
- W46001593 cites W1592032721 @default.
- W46001593 cites W1663635727 @default.
- W46001593 cites W1930648416 @default.
- W46001593 cites W194705401 @default.
- W46001593 cites W1960235333 @default.
- W46001593 cites W1974851643 @default.
- W46001593 cites W1977913272 @default.
- W46001593 cites W1984435363 @default.
- W46001593 cites W1993986769 @default.
- W46001593 cites W1996152157 @default.
- W46001593 cites W1998675277 @default.
- W46001593 cites W2008312229 @default.
- W46001593 cites W2016085666 @default.
- W46001593 cites W2017065604 @default.
- W46001593 cites W2022486030 @default.
- W46001593 cites W2027505310 @default.
- W46001593 cites W2031669929 @default.
- W46001593 cites W2033492040 @default.
- W46001593 cites W2038640078 @default.
- W46001593 cites W2039919570 @default.
- W46001593 cites W2039979639 @default.
- W46001593 cites W2040112038 @default.
- W46001593 cites W2043186109 @default.
- W46001593 cites W2044147277 @default.
- W46001593 cites W2060489436 @default.
- W46001593 cites W2062028511 @default.
- W46001593 cites W2067185719 @default.
- W46001593 cites W2067618246 @default.
- W46001593 cites W2068868786 @default.
- W46001593 cites W2071415265 @default.
- W46001593 cites W2076198413 @default.
- W46001593 cites W2084993477 @default.
- W46001593 cites W2086618933 @default.
- W46001593 cites W2093179980 @default.
- W46001593 cites W2105441566 @default.
- W46001593 cites W2107794446 @default.
- W46001593 cites W2109276727 @default.
- W46001593 cites W2109442096 @default.
- W46001593 cites W2111665940 @default.
- W46001593 cites W2113169771 @default.
- W46001593 cites W2113237744 @default.
- W46001593 cites W2113946177 @default.
- W46001593 cites W2119005151 @default.
- W46001593 cites W2122596811 @default.
- W46001593 cites W2123004798 @default.
- W46001593 cites W2132832238 @default.
- W46001593 cites W2134544592 @default.
- W46001593 cites W2135843106 @default.
- W46001593 cites W2137157133 @default.
- W46001593 cites W2137787563 @default.
- W46001593 cites W2138216198 @default.
- W46001593 cites W2140384293 @default.
- W46001593 cites W2142978323 @default.
- W46001593 cites W2143684983 @default.
- W46001593 cites W2144128200 @default.
- W46001593 cites W2147683057 @default.
- W46001593 cites W2150740393 @default.
- W46001593 cites W2166317148 @default.
- W46001593 cites W2166526425 @default.
- W46001593 cites W2168379509 @default.
- W46001593 cites W2170142229 @default.
- W46001593 cites W2186589950 @default.
- W46001593 cites W28190658 @default.
- W46001593 cites W4313347827 @default.
- W46001593 cites W4322388507 @default.
- W46001593 cites W60865865 @default.
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- W46001593 doi "https://doi.org/10.2119/2005-00044.belessi" @default.
- W46001593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1449522" @default.
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- W46001593 hasPublicationYear "2005" @default.
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