Matches in SemOpenAlex for { <https://semopenalex.org/work/W46029690> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W46029690 abstract "A novel tandem process has been developed for the stereoselective synthesis of bicyclic γ-lactams. Treatment of an allylic alcohol with trichloroacetonitrile, in the presence of DBU, affords the corresponding allylic trichloroacetimidate. This is then subjected to a tandem Overman rearrangement/RCM/Kharasch cyclisation, forming the desired bicyclic lactam in high yield and high enantiomeric excess. Overall, the one-pot tandem process involves three mechanistically distinct processes catalysed by palladium(II) (step 1) and Grubbs 1st generation catalyst (steps 2 and 3). The use of a thermal Overman rearrangement in tandem with the Grubbs catalysed RCM/Kharasch cyclisation was also investigated. Furthermore, a microwave-assisted tandem process was developed which resulted in the accelerated synthesis of the desired bicyclic γ-lactams. A two-step tandem process was then developed for the synthesis of bicyclic allylic amides, a closely related core unit to that found in a number of important commercially available drugs. Finally, progress has been made towards the total synthesis of (±)-deethylibophyllidine, which will utilise a tandem RCM/Kharasch cyclisation to construct the C and D rings of the natural product." @default.
- W46029690 created "2016-06-24" @default.
- W46029690 creator A5054733330 @default.
- W46029690 date "2012-01-01" @default.
- W46029690 modified "2023-09-24" @default.
- W46029690 title "The development of one-pot tandem reactions for the synthesis of polycyclic y-lactams" @default.
- W46029690 hasPublicationYear "2012" @default.
- W46029690 type Work @default.
- W46029690 sameAs 46029690 @default.
- W46029690 citedByCount "0" @default.
- W46029690 crossrefType "dissertation" @default.
- W46029690 hasAuthorship W46029690A5054733330 @default.
- W46029690 hasConcept C120095180 @default.
- W46029690 hasConcept C153914509 @default.
- W46029690 hasConcept C159985019 @default.
- W46029690 hasConcept C161790260 @default.
- W46029690 hasConcept C178790620 @default.
- W46029690 hasConcept C185592680 @default.
- W46029690 hasConcept C192562407 @default.
- W46029690 hasConcept C21951064 @default.
- W46029690 hasConcept C24961977 @default.
- W46029690 hasConcept C2777814067 @default.
- W46029690 hasConcept C44228677 @default.
- W46029690 hasConcept C486523 @default.
- W46029690 hasConcept C521977710 @default.
- W46029690 hasConcept C58548122 @default.
- W46029690 hasConcept C71240020 @default.
- W46029690 hasConceptScore W46029690C120095180 @default.
- W46029690 hasConceptScore W46029690C153914509 @default.
- W46029690 hasConceptScore W46029690C159985019 @default.
- W46029690 hasConceptScore W46029690C161790260 @default.
- W46029690 hasConceptScore W46029690C178790620 @default.
- W46029690 hasConceptScore W46029690C185592680 @default.
- W46029690 hasConceptScore W46029690C192562407 @default.
- W46029690 hasConceptScore W46029690C21951064 @default.
- W46029690 hasConceptScore W46029690C24961977 @default.
- W46029690 hasConceptScore W46029690C2777814067 @default.
- W46029690 hasConceptScore W46029690C44228677 @default.
- W46029690 hasConceptScore W46029690C486523 @default.
- W46029690 hasConceptScore W46029690C521977710 @default.
- W46029690 hasConceptScore W46029690C58548122 @default.
- W46029690 hasConceptScore W46029690C71240020 @default.
- W46029690 hasLocation W460296901 @default.
- W46029690 hasOpenAccess W46029690 @default.
- W46029690 hasPrimaryLocation W460296901 @default.
- W46029690 hasRelatedWork W1559456956 @default.
- W46029690 hasRelatedWork W1971271015 @default.
- W46029690 hasRelatedWork W1978392155 @default.
- W46029690 hasRelatedWork W2022838786 @default.
- W46029690 hasRelatedWork W2029956575 @default.
- W46029690 hasRelatedWork W2039874826 @default.
- W46029690 hasRelatedWork W2076556654 @default.
- W46029690 hasRelatedWork W2125688283 @default.
- W46029690 hasRelatedWork W2154553358 @default.
- W46029690 hasRelatedWork W2173996558 @default.
- W46029690 hasRelatedWork W2179014424 @default.
- W46029690 hasRelatedWork W2502525502 @default.
- W46029690 hasRelatedWork W2949394271 @default.
- W46029690 hasRelatedWork W2949855638 @default.
- W46029690 hasRelatedWork W2950373924 @default.
- W46029690 hasRelatedWork W2952258781 @default.
- W46029690 hasRelatedWork W2952332608 @default.
- W46029690 hasRelatedWork W2953163516 @default.
- W46029690 hasRelatedWork W2953243606 @default.
- W46029690 hasRelatedWork W172476560 @default.
- W46029690 isParatext "false" @default.
- W46029690 isRetracted "false" @default.
- W46029690 magId "46029690" @default.
- W46029690 workType "dissertation" @default.