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- W46089043 abstract "Several psychopharmacological properties of tobacco smoking are believed to be mediated by central nicotinic receptors on mesolimbic dopamine (DA) neurons. Using in vivo electrochemical probes we monitored the extracellular levels of DA alone and also the levels of DOPAC and ascorbate, in the nucleus accumbens following systemic administration of nicotine (0.4 mg/kg SC). These studies used nicotine-naive, unanaesthetized freely-moving rats. Preliminary data suggest an initial (<20 min) decrease in accumbal DA following the first injection of nicotine. This decrease was not observed on the second injection day when the DA signal reached a higher maximum and had a longer duration of effect." @default.
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- W46089043 date "1995-01-01" @default.
- W46089043 modified "2023-09-23" @default.
- W46089043 title "Measuring Changes in Mesolimbic Dopamine and Related Substances in Response to Systemic Nicotine Using in Vivo Electrochemistry" @default.
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- W46089043 doi "https://doi.org/10.1007/978-3-0348-7445-8_49" @default.
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