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- W46101990 abstract "Antibody production to type III pneumococcal polysaccharide (SIII) is not reduced in mice deprived of T cells (1). The properties of the antigen which enable it to trigger a “thymus-independent” B cell response are not understood but several unusual features can be listed. SIII contains few antigenic determinants, it persists in vivo for long periods of time, and can “neutralize” circulating anti-SIII antibody. Macroglobulin is the predominant antibody elicited by purified SIII in mice although immunization with the whole pneumococcal organism in various species results in 7S anti-SIII antibody. There is no evidence in any species that the purified antigen induces T cells to perform helper functions in antibody production, to elicit delayed hypersensitivity reactions, or to proliferate in vitro in response to the antigen (2 and 3 for recent reviews). The inability of SIII to engage T cells in immune responses may reflect an absence, or functional lack of expression, of V genes in T cells coding for the limited number of determinants on SIII or may reflect an extreme sensitivity of reactive T cells to tolerance induction by SIII." @default.
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- W46101990 date "1973-01-01" @default.
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- W46101990 title "Studies on the Influence of T Cells in Antibody Responses of Mice to SIII and DNP-Lysine-SIII" @default.
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- W46101990 doi "https://doi.org/10.1007/978-1-4615-9017-0_19" @default.
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