Matches in SemOpenAlex for { <https://semopenalex.org/work/W46147546> ?p ?o ?g. }
- W46147546 endingPage "175" @default.
- W46147546 startingPage "151" @default.
- W46147546 abstract "Mitochondria are key participants in cell death. They amplify death signals by releasing proapoptotic proteins normally stored in their intermembrane space, such as cytochrome c. In recent years, cytochrome c release has been demonstrated to be not only highly regulated by the proteins of the Bcl-2 family, but also influenced by changes in mitochondrial shape, including remodeling of the cristae and fragmentation of the cytosolic network, both orchestrated by a large group of “mitochondria-shaping” proteins. We focus our attention in this chapter on the involvement of mitochondrial shape changes in apoptosis and on their regulatory mechanisms. In particular, we discuss the roles of the pro-fusion OPA1 protein and of the inner mitochondrial membrane rhomboid PARL on cristae remodeling and apoptosis in mammals, and on the relationship among Bcl-2 family members, mitochondrial fragmentation, and cell death. These results open the possibility to modulate mitochondrial morphological changes in order to influence apoptosis and thus to intervene in the natural history of human diseases, from neurodegeneration to cancer." @default.
- W46147546 created "2016-06-24" @default.
- W46147546 creator A5051195022 @default.
- W46147546 creator A5068279446 @default.
- W46147546 date "2009-01-01" @default.
- W46147546 modified "2023-09-26" @default.
- W46147546 title "The Mitochondrial Pathway: Focus on Shape Changes" @default.
- W46147546 cites W1480948328 @default.
- W46147546 cites W1507812324 @default.
- W46147546 cites W1593219141 @default.
- W46147546 cites W1607777232 @default.
- W46147546 cites W1644794975 @default.
- W46147546 cites W1913661233 @default.
- W46147546 cites W1921965616 @default.
- W46147546 cites W1965705993 @default.
- W46147546 cites W1966241472 @default.
- W46147546 cites W1967445833 @default.
- W46147546 cites W1968505830 @default.
- W46147546 cites W1970248089 @default.
- W46147546 cites W1970650626 @default.
- W46147546 cites W1972044649 @default.
- W46147546 cites W1975836370 @default.
- W46147546 cites W1976720365 @default.
- W46147546 cites W1977258127 @default.
- W46147546 cites W1978559408 @default.
- W46147546 cites W1979489548 @default.
- W46147546 cites W1981592463 @default.
- W46147546 cites W1983216661 @default.
- W46147546 cites W1984547206 @default.
- W46147546 cites W1986124091 @default.
- W46147546 cites W1986568749 @default.
- W46147546 cites W1987785848 @default.
- W46147546 cites W1987845572 @default.
- W46147546 cites W1989540421 @default.
- W46147546 cites W1990098732 @default.
- W46147546 cites W1993059855 @default.
- W46147546 cites W1993490757 @default.
- W46147546 cites W1994611236 @default.
- W46147546 cites W1996234796 @default.
- W46147546 cites W1999053124 @default.
- W46147546 cites W2000352412 @default.
- W46147546 cites W2000834350 @default.
- W46147546 cites W2002973070 @default.
- W46147546 cites W2003705213 @default.
- W46147546 cites W2004968462 @default.
- W46147546 cites W2006897943 @default.
- W46147546 cites W2007289467 @default.
- W46147546 cites W2008715871 @default.
- W46147546 cites W2008841394 @default.
- W46147546 cites W2009278410 @default.
- W46147546 cites W2012173926 @default.
- W46147546 cites W2012974735 @default.
- W46147546 cites W2013091489 @default.
- W46147546 cites W2015594876 @default.
- W46147546 cites W2019986722 @default.
- W46147546 cites W2020052494 @default.
- W46147546 cites W2021258712 @default.
- W46147546 cites W2022161896 @default.
- W46147546 cites W2022827866 @default.
- W46147546 cites W2024595059 @default.
- W46147546 cites W2024996523 @default.
- W46147546 cites W2025713422 @default.
- W46147546 cites W2030145039 @default.
- W46147546 cites W2030351931 @default.
- W46147546 cites W2031293088 @default.
- W46147546 cites W2032446466 @default.
- W46147546 cites W2033111353 @default.
- W46147546 cites W2036851802 @default.
- W46147546 cites W2039276913 @default.
- W46147546 cites W2042196731 @default.
- W46147546 cites W2042409437 @default.
- W46147546 cites W2045085957 @default.
- W46147546 cites W2049873418 @default.
- W46147546 cites W2054164997 @default.
- W46147546 cites W2054820743 @default.
- W46147546 cites W2057713336 @default.
- W46147546 cites W2057843591 @default.
- W46147546 cites W2059009119 @default.
- W46147546 cites W2060811345 @default.
- W46147546 cites W2062853648 @default.
- W46147546 cites W2063362926 @default.
- W46147546 cites W2065018825 @default.
- W46147546 cites W2067568265 @default.
- W46147546 cites W2071229320 @default.
- W46147546 cites W2073028327 @default.
- W46147546 cites W2073095545 @default.
- W46147546 cites W2075477970 @default.
- W46147546 cites W2076337849 @default.
- W46147546 cites W2079676584 @default.
- W46147546 cites W2085058400 @default.
- W46147546 cites W2085184384 @default.
- W46147546 cites W2085441242 @default.
- W46147546 cites W2090466136 @default.
- W46147546 cites W2091489629 @default.
- W46147546 cites W2093628776 @default.
- W46147546 cites W2094113524 @default.
- W46147546 cites W2095022409 @default.
- W46147546 cites W2097007474 @default.