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- W46157225 abstract "In a recent consensus report sponsored by the American Gastroenterological Association Institute and the North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition, eosinophilic esophagitis (EoE) is defined as “a primary clinicopathologic disorder of the esophagus, characterized by esophageal and/or upper gastrointestinal tract symptoms in association with esophageal mucosal biopsy specimens containing ≥15 intraepithelial eosinophils/HPF and the absence of pathologic gastroesophageal reflux disease (GERD) as evidenced by a normal pH monitoring study of the distal esophagus or lack of response to high-dose proton pump inhibitor (PPI) medication. This definition implies that GERD and EoE are mutually exclusive disorders, and that GERD can be defined by an abnormal pH monitoring result or a lack of response to PPI therapy. Esophageal pH monitoring has substantial limitations as a test for GERD, and some patients who have verified reflux esophagitis can have normal esophageal pH monitoring results. Lack of response to PPI therapy is, at best, a subjective index for GERD, and even a positive response to PPI therapy may not be due to the control of acid reflux. There is much evidence to suggest that the interaction between GERD and EoE can be complex, and that the notion of establishing a clear distinction between the two disorders is too simplistic. Indeed, many investigators have chosen to include subjects with abnormal acid reflux documented by pH monitoring in their series of patients with EoE." @default.
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- W46157225 date "2011-08-20" @default.
- W46157225 modified "2023-10-17" @default.
- W46157225 title "Relationship of Eosinophilic Esophagitis to Gastroesophageal Reflux" @default.
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- W46157225 doi "https://doi.org/10.1007/978-1-60761-515-6_11" @default.
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