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- W46158141 abstract "This chapter reviews knowledge of bacterial swarming and the likely underlying mechanisms, focusing principally on studies of Proteus mirabilis. Swarming P. mirabilis produces very large spreading colonies in which concentric zonation, or terracing, results from periodic cycles of mass migration interspersed with population growth without expansion of the colony edge. A role for bacterial motility has been demonstrated in a variety of pathogen-host interactions. Histological analysis of renal tissues from mice infected by wild-type P. mirabilis revealed that differentiated cells were the major invasive cell type. The chapter focuses on molecular analysis of swarming differentiation and migration. Environmental attractants or repellents are recognized by transmembrane receptors, the methyl-accepting chemotaxis proteins (MCPs), that transduce signals to the cytoplasmic components of the chemotaxis phosphorelay, CheWAY. The physiological status of P. mirabilis cells affects their ability to swarm, as high growth rates of vegetative cells on nutrient-rich solid medium stimulate differentiation. Cell-cell contact is stabilized by the production of cell-surface polysaccharides that form a slime capsule around groups of P. mirabilis swarm cells. The primary function of FlhDC is the control of flagella biogenesis, but in Escherichia coli, Serratia liquefaciens, and P. mirabilis FlhDC also represses cell division. The hyperexpression of the flagellar gene hierarchy in Proteus has highlighted induction and negative regulation barely evident in undifferentiated cells, and the coupling of swarming to virulence, whether through an intrinsic role in colonization or coregulation of motility and virulence genes, adds an additional level of significance." @default.
- W46158141 created "2016-06-24" @default.
- W46158141 creator A5023857996 @default.
- W46158141 creator A5058251759 @default.
- W46158141 creator A5058630623 @default.
- W46158141 date "2014-04-08" @default.
- W46158141 modified "2023-09-24" @default.
- W46158141 title "Swarming Migration by Proteus and Related Bacteria" @default.
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