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- W46228081 abstract "The proto-oncogene protein kinase B (PKB) is activated by the lipid second messenger phosphotidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P], but the mechanism is just now becoming clear. In this issue, Stokoe et al . show that another kinase, the upstream kinase, phosphorylates and partially activates PKB only when PtdIns(3,4,5)Pboth activates the upstream kinase and binds to PKB, causing a conformational change that seems to expose the phosphorylation site. In his Perspective, Hemmings discusses the significance of this dual regulation of this key kinase." @default.
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- W46228081 date "1997-07-25" @default.
- W46228081 modified "2023-10-17" @default.
- W46228081 title "Update: PtdIns(3,4,5)P <sub>3</sub> Gets Its Message Across" @default.
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- W46228081 doi "https://doi.org/10.1126/science.277.5325.534" @default.
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