FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W46286119> ?p ?o ?g. }

• W46286119 endingPage "106" @default.
• W46286119 startingPage "99" @default.
• W46286119 abstract "Human xanthomas derived from four subjects with familial hypercholesterolemia (3 homozygotes and 1 heterozygote) were studied by immunohistochemical methods to determine the presence and distribution of lipoproteins, which have been implicated in the pathogenesis of atherosclerosis. Oxidatively modified low-density lipoprotein (OxLDL) epitopes detected with anti-OxLDL monoclonal antibodies, appeared to have a similar distribution in xanthomata to that of macrophages, detected by a cell-specific monoclonal antibody. Double antibody labeling with both an anti-macrophage antibody and an anti-OxLDL antibody demonstrated that OxLDL epitopes are associated with macrophages and occurred intracellularly. Low-density lipoprotein (LDL) epitopes were detected extracellularly, with a distribution that was different from that of OxLDL. In addition, apo(a) epitopes detected by an apo(a) specific monoclonal antibody, had a distribution similar to that of LDL in the dermis and subcutaneous tissues. The observed epitope distribution of LDL, OxLDL, or apo(a) was the same regardless of the method of treatment of the patients from whom the xanthomas were obtained (probucol, simvastatin, LDL apheresis). These findings suggest that OxLDL is likely to play a pathogenetic role in the lipid accumulation by macrophages in xanthomas, and suggest that Lp(a) also may play a role in their pathogenesis." @default.
• W46286119 created "2016-06-24" @default.
• W46286119 creator A5022745436 @default.
• W46286119 creator A5053482415 @default.
• W46286119 creator A5067464347 @default.
• W46286119 creator A5070052551 @default.
• W46286119 creator A5080534060 @default.
• W46286119 creator A5081159079 @default.
• W46286119 date "1992-07-01" @default.
• W46286119 modified "2023-09-23" @default.
• W46286119 title "Immunohistochemical distribution of lipoprotein epitopes in xanthomata from patients with familial hypercholesterolemia." @default.
• W46286119 cites W152815097 @default.
• W46286119 cites W1564079839 @default.
• W46286119 cites W1760305457 @default.
• W46286119 cites W1832637442 @default.
• W46286119 cites W1841536119 @default.
• W46286119 cites W1857052429 @default.
• W46286119 cites W1968679020 @default.
• W46286119 cites W1972444318 @default.
• W46286119 cites W1976485306 @default.
• W46286119 cites W1977492767 @default.
• W46286119 cites W1977778060 @default.
• W46286119 cites W1997354164 @default.
• W46286119 cites W2005230846 @default.
• W46286119 cites W2012098057 @default.
• W46286119 cites W2017315967 @default.
• W46286119 cites W2040579726 @default.
• W46286119 cites W2049401036 @default.
• W46286119 cites W2055111376 @default.
• W46286119 cites W2064179373 @default.
• W46286119 cites W2067870659 @default.
• W46286119 cites W2069198858 @default.
• W46286119 cites W2069871128 @default.
• W46286119 cites W2102920246 @default.
• W46286119 cites W2116371832 @default.
• W46286119 cites W2118721393 @default.
• W46286119 cites W2156315439 @default.
• W46286119 cites W2188261369 @default.
• W46286119 cites W2347099432 @default.
• W46286119 cites W2412232087 @default.
• W46286119 cites W2419450547 @default.
• W46286119 cites W350446038 @default.
• W46286119 cites W2083267747 @default.
• W46286119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1886588" @default.
• W46286119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1378698" @default.
• W46286119 hasPublicationYear "1992" @default.
• W46286119 type Work @default.
• W46286119 sameAs 46286119 @default.
• W46286119 citedByCount "6" @default.
• W46286119 countsByYear W462861192016 @default.
• W46286119 countsByYear W462861192019 @default.
• W46286119 countsByYear W462861192022 @default.
• W46286119 crossrefType "journal-article" @default.
• W46286119 hasAuthorship W46286119A5022745436 @default.
• W46286119 hasAuthorship W46286119A5053482415 @default.
• W46286119 hasAuthorship W46286119A5067464347 @default.
• W46286119 hasAuthorship W46286119A5070052551 @default.
• W46286119 hasAuthorship W46286119A5080534060 @default.
• W46286119 hasAuthorship W46286119A5081159079 @default.
• W46286119 hasConcept C126322002 @default.
• W46286119 hasConcept C134018914 @default.
• W46286119 hasConcept C159654299 @default.
• W46286119 hasConcept C163864487 @default.
• W46286119 hasConcept C185592680 @default.
• W46286119 hasConcept C195616568 @default.
• W46286119 hasConcept C203014093 @default.
• W46286119 hasConcept C204232928 @default.
• W46286119 hasConcept C2776167589 @default.
• W46286119 hasConcept C2778163477 @default.
• W46286119 hasConcept C2779120738 @default.
• W46286119 hasConcept C2779620165 @default.
• W46286119 hasConcept C2780072125 @default.
• W46286119 hasConcept C2780942790 @default.
• W46286119 hasConcept C542903549 @default.
• W46286119 hasConcept C62746215 @default.
• W46286119 hasConcept C71924100 @default.
• W46286119 hasConcept C86803240 @default.
• W46286119 hasConceptScore W46286119C126322002 @default.
• W46286119 hasConceptScore W46286119C134018914 @default.
• W46286119 hasConceptScore W46286119C159654299 @default.
• W46286119 hasConceptScore W46286119C163864487 @default.
• W46286119 hasConceptScore W46286119C185592680 @default.
• W46286119 hasConceptScore W46286119C195616568 @default.
• W46286119 hasConceptScore W46286119C203014093 @default.
• W46286119 hasConceptScore W46286119C204232928 @default.
• W46286119 hasConceptScore W46286119C2776167589 @default.
• W46286119 hasConceptScore W46286119C2778163477 @default.
• W46286119 hasConceptScore W46286119C2779120738 @default.
• W46286119 hasConceptScore W46286119C2779620165 @default.
• W46286119 hasConceptScore W46286119C2780072125 @default.
• W46286119 hasConceptScore W46286119C2780942790 @default.
• W46286119 hasConceptScore W46286119C542903549 @default.
• W46286119 hasConceptScore W46286119C62746215 @default.
• W46286119 hasConceptScore W46286119C71924100 @default.
• W46286119 hasConceptScore W46286119C86803240 @default.
• W46286119 hasIssue "1" @default.
• W46286119 hasLocation W462861191 @default.
• W46286119 hasOpenAccess W46286119 @default.

• next