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- W46290131 abstract "In patients with staghorn nephrolithiasis, metabolic diagnosis can reveal renal calculi formation of various etiology, such as hypercalcemia and hypercalciuria, hyperphosphatemia/uria, hyperuricosemia/uria, hypomagnesaemia/uria, (hyper)oxaluria, hypercystinuria, hypocitraturia and metabolic acidosis. However, in most cases the cause of stone formation cannot be accurately determined. In 2011 year in our clinic 54 patients underwent percutaneous nephrolithotomy. A comprehensive biochemistry blood investigation and a 24-hour urine test were performed. For mineral composition assessment of an extracted stone, an X-ray examination was carried out. In 89.9% of patients, blood and 24-hour urine analyses revealed metabolic disturbances, but the conformance of the pathologic metabolic changes to the chemical composition of staghorn calculi were detected only in 51.8% of cases. The proportion of the hyperuricosuria/ hyperuricosemia, hypercalciaemia/hypercalciuria, hyperoxaluria, and hyperphosphaturia was 42.9%, 28.6%, 21.4% and 7.1%, respectively. The discordance of the blood and urine metabolic changes and results of a calculi X-ray analysis was observed in 48.2% cases. Thus, an evaluation of the metabolic changes and their correlation to calculi chemical composition ensures a reduction of lithogenicity level and an increase in crystallization and aggregation inhibitors concentration in both blood and urine, additionally allowing to avoid unnecessary adjunctive interventions of no etiological or pathophysiological basis." @default.
- W46290131 created "2016-06-24" @default.
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- W46290131 date "2012-01-01" @default.
- W46290131 modified "2023-09-26" @default.
- W46290131 title "Особенности минеральных метаболических изменений крови и мочи у больных коралловидным нефролитиазом Южного региона России" @default.
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